Molecular Mechanisms of Staphylococcus aureus Iron Acquisition

ND Hammer, EP Skaar - Annual review of microbiology, 2011 - annualreviews.org
Iron acquisition is required for S. … In addition to iron acquisition systems, this analysis
revealed an increase in glycolytic and fermentative enzymes, indicating that S. …

Staphylococcus aureus heme and siderophore-iron acquisition pathways

BS Conroy, JC Grigg, M Kolesnikov, LD Morales… - Biometals, 2019 - Springer
… of iron from the human host, but iron is highly restricted in this environment. Staphylococcus
aureus iron sufficiency is achieved primarily through uptake of heme and high-affinity iron

Staphylococcus aureus siderophore-mediated iron-acquisition system plays a dominant and essential role in the utilization of transferrin-bound iron

PR Young, SH Yu, CM Hwa, BY Hoon… - Journal of …, 2005 - koreascience.kr
… Most pathogenic bacteria utilize high-affinity ironacquisition systems to counter the limited
iron-availability in their hosts. The iron-acquisition systems of Gram-negative bacteria have …

Staphylococcus aureus redirects central metabolism to increase iron availability

DB Friedman, DL Stauff, G Pishchany… - PLoS …, 2006 - journals.plos.org
… the availability of nutrient iron. Based on the well-established role for bacterial iron acquisition
during pathogenesis, systems involved in iron acquisition represent excellent potential …

Iron-Source Preference of Staphylococcus aureus Infections

EP Skaar, M Humayun, T Bae, KL DeBord… - Science, 2004 - science.org
… We applied this technique to iron (Fe) acquisition in S. … Fe acquisition and supports the
results presented in Fig. 1, suggesting temporal regulation of iron acquisition systems. …

Recent developments in understanding the iron acquisition strategies of gram positive pathogens

JR Sheldon, DE Heinrichs - FEMS microbiology reviews, 2015 - academic.oup.com
… elucidation of heme–iron extraction, and heme … iron acquisition strategies of notorious
Gram-positive pathogens and highlights how both conserved and distinct tactics for acquiring iron

Metal ion acquisition in Staphylococcus aureus: overcoming nutritional immunity

JE Cassat, EP Skaar - Seminars in immunopathology, 2012 - Springer
… -mediated iron acquisition by staphyloferrin A and B, S. … iron acquisition promotes
staphylococcal growth in iron-limited conditions in vitro and in vivo, the preferred iron source for S. …

Staphylococcus aureus but not Staphylococcus epidermidis can acquire iron from transferrin

JA Lindsay, TV Riley, BJ Mee - Microbiology, 1995 - microbiologyresearch.org
… To determine if staphylococci can extract iron bound to human transferrin, we labelled … in
iron-restricted and iron-plentiful conditions. Growing cultures of Staphylococcus aureus NCTC …

The Role of Iron in Staphylococcus aureus Infection and Human Disease: A Metal Tug of War at the Host—Microbe Interface

MC van Dijk, RM de Kruijff… - Frontiers in cell and …, 2022 - frontiersin.org
Iron deficiency anemia can be treated with oral or … of Fe by the opportunistic pathogen
Staphylococcus aureus. Ferric uptake … for heme iron as an Fe source, which is enabled by the Iron-…

Staphylococcus aureus growth using human hemoglobin as an iron source

G Pishchany, KP Haley, EP Skaar - JoVE (Journal of Visualized …, 2013 - jove.com
iron acquisition and growth has proven to be more challenging. Growth assays using
hemoglobin as a sole iron … free iron in the growth medium, and toxicity associated with iron