Molecular Mechanisms of Staphylococcus aureus Iron Acquisition

ND Hammer, EP Skaar - Annual review of microbiology, 2011 - annualreviews.org
… to iron acquisition systems, this analysis revealed an increase in glycolytic and fermentative
enzymes, indicating that S. … built into staphylococcal iron acquisition systems guarantees the …

Staphylococcus aureus heme and siderophore-iron acquisition pathways

BS Conroy, JC Grigg, M Kolesnikov, LD Morales… - Biometals, 2019 - Springer
… of iron from the human host, but iron is highly restricted in this environment. Staphylococcus
aureus iron sufficiency is achieved primarily through uptake of heme and high-affinity iron

Staphylococcus aureus siderophore-mediated iron-acquisition system plays a dominant and essential role in the utilization of transferrin-bound iron

PR Young, SH Yu, CM Hwa, BY Hoon… - Journal of …, 2005 - koreascience.kr
… Most pathogenic bacteria utilize high-affinity ironacquisition systems to counter the limited
iron-availability in their hosts. The iron-acquisition systems of Gram-negative bacteria have …

Staphylococcus aureus redirects central metabolism to increase iron availability

DB Friedman, DL Stauff, G Pishchany… - PLoS …, 2006 - journals.plos.org
… a strong correlation between expression changes upon iron chelation versus the absence
of Fur. As expected, iron acquisition systems previously shown to be iron-regulated via Fur are …

Recent developments in understanding the iron acquisition strategies of gram positive pathogens

JR Sheldon, DE Heinrichs - FEMS microbiology reviews, 2015 - academic.oup.com
… elucidation of heme–iron extraction, and heme … iron acquisition strategies of notorious
Gram-positive pathogens and highlights how both conserved and distinct tactics for acquiring iron

Iron-Source Preference of Staphylococcus aureus Infections

EP Skaar, M Humayun, T Bae, KL DeBord… - Science, 2004 - science.org
system), a gene cluster that promotes preferred heme iron import by … acquisition and supports
the results presented in Fig. 1, suggesting temporal regulation of iron acquisition systems. …

Metal ion acquisition in Staphylococcus aureus: overcoming nutritional immunity

JE Cassat, EP Skaar - Seminars in immunopathology, 2012 - Springer
… knowledge of staphylococcal metal ion acquisition systems, as … of nutritional immunity
during staphylococcal infection. … iron acquisition promotes staphylococcal growth in iron-limited …

Altered immune proteome of Staphylococcus aureus under iron‐restricted growth conditions

S Stentzel, HC Vu, AM Weyrich, N Jehmlich… - …, 2014 - Wiley Online Library
… Quantification of the secreted bacterial proteins by gel-free proteomics showed the expected
strong increase in level of proteins involved in iron acquisition during iron-restricted growth …

Siderophore-mediated iron acquisition in the staphylococci

FC Beasley, DE Heinrichs - Journal of inorganic biochemistry, 2010 - Elsevier
… A few are capable of causing disease, especially in an opportunistic fashion; the most
studied pathogenic species is Staphylococcus aureus. Superficial colonization by …

Staphylococcus aureus growth using human hemoglobin as an iron source

G Pishchany, KP Haley, EP Skaar - JoVE (Journal of Visualized …, 2013 - jove.com
… Further, the contribution of the Isd systemsystem to hemoglobin-derived iron acquisition
and growth has proven to be more challenging. Growth assays using hemoglobin as a sole iron