Molecular Mechanisms of Staphylococcus aureus Iron Acquisition

ND Hammer, EP Skaar - Annual review of microbiology, 2011 - annualreviews.org
iron acquisition systems, this analysis revealed an increase in glycolytic and fermentative
enzymes, indicating that Saureus grown in iron-replete conditions transports exogenous heme …

Staphylococcus aureus heme and siderophore-iron acquisition pathways

BS Conroy, JC Grigg, M Kolesnikov, LD Morales… - Biometals, 2019 - Springer
… of iron from the human host, but iron is highly restricted in this environment. Staphylococcus
aureus iron … Humans have iron transport and scavenging systems that use proteins such as …

[HTML][HTML] Staphylococcus aureus redirects central metabolism to increase iron availability

DB Friedman, DL Stauff, G Pishchany… - PLoS …, 2006 - journals.plos.org
… for bacterial iron acquisition during pathogenesis, systems involved in iron acquisition represent
… To explore the contribution of the Hrt system to heme transport, we investigated whether …

Iron-Source Preference of Staphylococcus aureus Infections

EP Skaar, M Humayun, T Bae, KL DeBord… - Science, 2004 - science.org
… genome analysis, we identified hts (heme transport system), a gene cluster that promotes
preferred heme iron import by S. … 1, suggesting temporal regulation of iron acquisition systems. …

Staphylococcus aureus siderophore-mediated iron-acquisition system plays a dominant and essential role in the utilization of transferrin-bound iron

PR Young, SH Yu, CM Hwa, BY Hoon… - Journal of …, 2005 - koreascience.kr
ironacquisition systems to counter the limited iron-availability in their hosts. The iron-acquisition
permease involved in iron-hydroxamate transport in Staphylococcus aureus. J. Bacteriol. …

Subcellular Localization of the Staphylococcus aureus Heme Iron Transport Components IsdA and IsdB

G Pishchany, SE Dickey, EP Skaar - Infection and immunity, 2009 - Am Soc Microbiol
aureus experiences various degrees of iron starvation depending on the site of infection. …
iron acquisition and demonstrate an orchestrated pattern of regulation and localization for the S

Requirement of Staphylococcus aureus ATP-Binding Cassette-ATPase FhuC for Iron-Restricted Growth and Evidence that It Functions with More than One Iron …

CD Speziali, SE Dale, JA Henderson… - Journal of …, 2006 - Am Soc Microbiol
… the result of an inability to transport iron in a complex with a staphylococcal siderophore. …
the ATPase FhuC is required for iron acquisition from both hydroxamate siderophores and the …

[HTML][HTML] Metal ion acquisition in Staphylococcus aureus: overcoming nutritional immunity

JE Cassat, EP Skaar - Seminars in immunopathology, 2012 - Springer
Transport of staphyloferrin B across the staphylococcal cell … iron acquisition promotes
staphylococcal growth in iron-limited conditions in vitro and in vivo, the preferred iron source for S. …

[HTML][HTML] The Role of Iron in Staphylococcus aureus Infection and Human Disease: A Metal Tug of War at the Host—Microbe Interface

MC van Dijk, RM de Kruijff… - Frontiers in cell and …, 2022 - frontiersin.org
… Fe by the opportunistic pathogen Staphylococcus aureus. Ferric … for heme iron as an Fe
source, which is enabled by the Iron-… Heme transfer from IsdI to SnbI has been suggested to help …

Iron Acquisition and Transport in Staphylococcus aureus

AW Maresso, O Schneewind - Biometals, 2006 - Springer
… A cell-wall based iron acquisition and import pathway was uncovered in Staphylococcus
aureus. This pathway, termed the isd or iron-responsive surface determinant locus, consists of a …