Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron

TH Flo, KD Smith, S Sato, DJ Rodriguez, MA Holmes… - Nature, 2004 - nature.com
… of lipocalin 2 against enterochelin-dependent bacterial infection, we supplied the bacteria
with a lipocalin-2-independent route of iron acquisition by adding ferrichrome, a hydroxamate-…

[引用][C] Correction: Iron and microbial infection

UE Schaible, SHE Kaufmann - Nature Reviews Microbiology, 2005 - nature.com
Of the predicted 3,974 genes on the chromosome, 75% have highly conserved (> 97% amino
acid identity) orthologues in Y. pestis (CO92 and KIM10). Like Y. pestis strains KIM, CO92 …

Lactoferrin: lactoferrin: an important host defence against microbial and viral attack

P Valenti, G Antonini - Cellular and Molecular Life Sciences, 2005 - Springer
infections in the gastrointestinal tract [8, 11–13] while promoting the growth of bacteria with
low iron … the level of available iron below that required to support microbial growth [21]. Indeed…

Iron fortification adversely affects the gut microbiome, increases pathogen abundance and induces intestinal inflammation in Kenyan infants

T Jaeggi, GAM Kortman, D Moretti, C Chassard… - Gut, 2015 - gut.bmj.com
… most of the iron passing unabsorbed into the colon. Once absorbed, iron in the body is
bound to proteins limiting iron access to potential pathogens, and during infection, iron supply is …

A saga of Hepcidin anti-microbial Effectiveness as Iron Acquisitor and Anemia Initiator in Mycobacterium Tuberculosis Infection

HA Waggiallah, LB Eltayeb, AS BinShaya… - Journal of …, 2020 - jbiochemtech.com
… require iron, TB should be capable of trapping iron from the host, and the host must modify
its iron spread in consequence to infection. … Even so, hepcidin exquisites the iron intracellular …

[HTML][HTML] Modulation of intramacrophage iron metabolism during microbial cell invasion

ED Weinberg - Microbes and infection, 2000 - Elsevier
The mechanisms whereby vertebrate hosts withhold iron from microbial invaders, as well as
the methods used in attempts by invaders to capture the growth-essential metal, differ …

Iron and immunity: a double‐edged sword

G Weiss - European journal of clinical investigation, 2002 - Wiley Online Library
… virus infection [63,64]. Other examples of infection where an aggravation of the disease by
iron is … Studies in patients with African iron overload have demonstrated that an increased iron

Hepcidin and ferritin predict microbial etiology in community-acquired pneumonia

K Oppen, T Ueland, WW Siljan… - Open Forum …, 2021 - academic.oup.com
infections induce changes in levels of iron and iron-related proteins that may differ among
groups of pathogens, we explored the ability of these potential biomarkers to predict microbial

Lactoferrin: balancing ups and downs of inflammation due to microbial infections

ME Drago-Serrano, R Campos-Rodríguez… - International journal of …, 2017 - mdpi.com
… Lactoferrin (Lf) is a conserved iron-binding mammalian … prophylactic treatments for microbial
infections that ameliorate both … is an iron binding protein involved in the control of iron levels …

[HTML][HTML] Association of hemochromatosis with infectious diseases: expanding spectrum

FA Khan, MA Fisher, RA Khakoo - International Journal of Infectious …, 2007 - Elsevier
… eliminates free iron from … iron present in body fluids, the amount of free iron is very small to
sustain bacterial growth. In addition, during infections the host reduces the total amount of iron