Novel iron-chelator DIBI inhibits Staphylococcus aureus growth, suppresses experimental MRSA infection in mice and enhances the activities of diverse antibiotics in …

MC Parquet, KA Savage, DS Allan… - Frontiers in …, 2018 - frontiersin.org
… antimicrobial polymer was studied for its anti-staphylococcal activities in vitro in comparison
chelator. The sensitivities of 18 clinical isolates of Staphylococcus aureus from human, …

[HTML][HTML] Staphylococcus aureus growth using human hemoglobin as an iron source

G Pishchany, KP Haley, EP Skaar - Journal of visualized …, 2013 - ncbi.nlm.nih.gov
aureus is a pathogenic bacterium that requires iron to carry … The most abundant reservoir
of iron inside the human host is … with iron chelator EDDHA and human hemoglobin is …

Structural Basis for Xenosiderophore Utilization by the Human Pathogen Staphylococcus aureus

NP Endicott, E Lee, TA Wencewicz - ACS Infectious Diseases, 2017 - ACS Publications
chelation therapy to treat human iron overload diseases and has been linked to an increased
risk of SStaphylococcus aureus is a Gram-positive human pathogen responsible for nearly …

Antibacterial activities of iron chelators against common nosocomial pathogens

MG Thompson, BW Corey, Y Si, DW Craft… - Antimicrobial agents …, 2012 - Am Soc Microbiol
… against bacteria may be superior to chelators previously tested. In the … (1, 21), iron chelators
that have already undergone toxicity and … MDR species, such as Staphylococcus aureus or …

… insight into the molecular structure, iron chelation, and biological activity of a polycarboxylate siderophore deployed by the human pathogen Staphylococcus aureus

JLH Madsen, TC Johnstone… - Journal of the American …, 2015 - ACS Publications
… by the human pathogen Staphylococcus aureus for acquiring iron … Under conditions of iron
limitation, addition of synthetic SB to … the growth of the antibiotic resistant community isolate S. …

Involvement of Iron in Biofilm Formation by Staphylococcus aureus

MH Lin, JC Shu, HY Huang, YC Cheng - PloS one, 2012 - journals.plos.org
Staphylococcus aureus is a human pathogen that forms biofilm on … iron-limiting conditions.
A chemical assay using ferrozine verifies that PGG is a strong iron chelator that depletes iron

Staphylococcus aureus redirects central metabolism to increase iron availability

DB Friedman, DL Stauff, G Pishchany… - … pathogens, 2006 - journals.plos.org
… available iron impacts the human pathogen Staphylococcus aureus, … in iron status. The
authors found that under conditions of … decreases upon iron chelation suggest that iron-starved S. …

The Role of Iron in Staphylococcus aureus Infection and Human Disease: A Metal Tug of War at the Host—Microbe Interface

MC van Dijk, RM de Kruijff… - Frontiers in cell and …, 2022 - frontiersin.org
… on the human microbiome, and on opportunistic pathogenic … Fe by the opportunistic pathogen
Staphylococcus aureus. Ferric … for heme iron as an Fe source, which is enabled by the Iron-…

Iron-Source Preference of Staphylococcus aureus Infections

EP Skaar, M Humayun, T Bae, KL DeBord… - Science, 2004 - science.org
… Thus, early during infection staphylococci appear to satisfy their iron requirements … iron
chelator, but this was found to selectively remove iron from transferrin, and therefore no chelator

… Proteomic View on Secreted, Cell Surface-Associated, and Cytoplasmic Proteins of the Methicillin-Resistant Human Pathogen Staphylococcus aureus under Iron …

K Hempel, FA Herbst, M Moche… - Journal of proteome …, 2011 - ACS Publications
… -limited conditions we added 0.75 mM of the high affinity iron chelator 2,2-bipyridyl (BIP)
to the medium. Addition of 0.75 mM BIP to exponentially growing cells led to a significantly …