Staphylococcus aureus redirects central metabolism to increase iron availability

DB Friedman, DL Stauff, G Pishchany… - PLoS …, 2006 - journals.plos.org
iron during infection. To gain insight into how the amount of available iron impacts the human
pathogen Staphylococcus aureus… in iron status. The authors found that under conditions of …

Molecular Mechanisms of Staphylococcus aureus Iron Acquisition

ND Hammer, EP Skaar - Annual review of microbiology, 2011 - annualreviews.org
… that allow for the acquisition of iron during infection. The gram-positive extracellular pathogen
Staphylococcus aureus is a commensal organism that … Iron acquisition is required for S. …

Iron-Source Preference of Staphylococcus aureus Infections

EP Skaar, M Humayun, T Bae, KL DeBord… - Science, 2004 - science.org
… To determine whether S. aureus exhibits source-dependent iron preference, we first serially
passaged bacteria in low-iron medium until a decrease in growth rate indicative of iron

The impact of metal sequestration on Staphylococcus aureus metabolism

ND Hammer, EP Skaar - Current opinion in microbiology, 2012 - Elsevier
aureus encounters an iron-deplete environment resulting in the expression of the staphylococcal
iron … These systems target the most abundant sources of iron, the iron-containing host …

Influence of iron depletion on growth kinetics, siderophore production, and protein expression of Staphylococcus aureus

D Trivier, M Davril, N Houdret… - FEMS microbiology …, 1995 - academic.oup.com
… 6] showed that the iron uptake mechanism of S. aureus grown under iron depletion involves
… Therefore the aim of this investigation was to analyse bacterial adaptation to iron starvation …

Staphylococcus aureus growth using human hemoglobin as an iron source

G Pishchany, KP Haley, EP Skaar - JoVE (Journal of Visualized …, 2013 - jove.com
… assay for Staphylococcus aureus using hemoglobin as the sole source of available nutrient
iron. This assay establishes the role of bacterial factors involved in hemoglobin-derived iron

Staphylococcus aureus haem oxygenases are differentially regulated by iron and haem

ML Reniere, EP Skaar - Molecular microbiology, 2008 - Wiley Online Library
… to growth in vertebrates, Staphylococcus aureus elaborates the iron-regulated surface
determinant system (Isd), which is responsible for capturing nutrient iron from host haem and …

Altered immune proteome of Staphylococcus aureus under iron‐restricted growth conditions

S Stentzel, HC Vu, AM Weyrich, N Jehmlich… - …, 2014 - Wiley Online Library
Staphylococcus aureus is further able to acquire iron by a siderophore-mediated iron-…
and staphyloferrin B, which sequester iron from human transferrin and holotransferrin. The …

Effects of iron depletion and sab-inhibitory concentrations of antibiotics on siderophore production by Staphylococcus aureus

RJ Courcol, PA Lambert, P Fournier… - Journal of …, 1991 - academic.oup.com
The effect of various sub-MICs of oxacillin and amikarin, alone or in combination, on
siderophore production by Staphylococcus aureus growing under iron-depleted conditions was …

Metal ion acquisition in Staphylococcus aureus: overcoming nutritional immunity

JE Cassat, EP Skaar - Seminars in immunopathology, 2012 - Springer
… The most well characterized example of nutritional immunity during staphylococcal infection
is iron sequestration, in which iron is maintained predominantly intracellularly or in complex …