[HTML][HTML] Iron dyshomeostasis and ferroptosis: a new Alzheimer's disease hypothesis?

F Wang, J Wang, Y Shen, H Li, WD Rausch… - Frontiers in aging …, 2022 - frontiersin.org
… AD pathogenesis with iron dyshomeostasis and ferroptosis, in order to highlight the hypothesis
regarding iron-induced AD and the possibility of targeting iron and ferroptosis to treat AD. …

The relationship between iron dyshomeostasis and amyloidogenesis in Alzheimer's disease: two sides of the same coin

DG Peters, JR Connor, MD Meadowcroft - Neurobiology of disease, 2015 - Elsevier
… homeostasis, and cerebral amyloid angiopathy (CAA) is not fully understood, we
hypothesize that brain perfusion and iron dyshomeostasis are related to amyloid generation. …

Iron dyshomeostasis in Parkinson's disease

J Salazar, N Mena, MT Nunez - Oxidative Stress and Neuroprotection, 2006 - Springer
… We hypothesize that he presence of high levels of DMT1 in SNpc might explain its higher …
We hypothesize that dopaminergic cells, which abundantly express TNFa receptors (Boka …

Targeting iron dyshomeostasis for treatment of neurodegenerative disorders

N Bergsland, E Tavazzi, F Schweser, D Jakimovski… - CNS drugs, 2019 - Springer
diseases and the role of imaging in monitoring brain iron. Finally, we assess potential therapies
aimed towards targeting iron dyshomeostasis… supports the hypothesis that iron plays a …

The emerging role of iron dyshomeostasis in the mitochondrial decay of aging

J Xu, E Marzetti, AY Seo, JS Kim, TA Prolla… - Mechanisms of ageing …, 2010 - Elsevier
… Such damage is thought to play a major role in the pathogenesis of iron overload
diseases and age-related pathologies. Indeed, recent findings of the beneficial effects of …

Mini-review: is iron-mediated cell death (ferroptosis) an identical factor contributing to the pathogenesis of some neurodegenerative diseases?

A Viktorinova, M Durfinova - Neuroscience Letters, 2021 - Elsevier
… The review article briefly discusses a hypothesis based on the potential participation of iron
… some neurodegenerative diseases. Iron dyshomeostasis (especially cellular iron overload) …

Disturbance of redox homeostasis in Down Syndrome: Role of iron dysmetabolism

E Barone, A Arena, E Head, DA Butterfield… - Free Radical Biology and …, 2018 - Elsevier
… In support to this hypothesis, we analyzed proteasome activity and autophagic flux in DS brain
… within astrocytes observed in neurodenegerative diseases [100]. Thus, it is reasonable to …

[HTML][HTML] Homocysteine, iron and cardiovascular disease: a hypothesis

JE Baggott, T Tamura - Nutrients, 2015 - mdpi.com
… above, we hypothesize that an iron-dependent chemical … certain extent, a surrogate for body
iron stores and Met intake. We … The “Hcy-CVD” hypothesis regrettably began with the report …

[HTML][HTML] Iron homeostasis disorder and Alzheimer's disease

Y Peng, X Chang, M Lang - International journal of molecular sciences, 2021 - mdpi.com
… cures for the disease. This paper … iron and AD from the aspects of iron absorption in intestinal
cells, storage and regulation of iron in cells and organs, especially for the regulation of iron

[HTML][HTML] … as the major driver of and explanation for neuropathogenesis, the cholinergic hypothesis, iron dyshomeostasis, and salivary lactoferrin in Alzheimer's disease

PL Nara, D Sindelar, MS Penn… - … Disease, 2021 - content.iospress.com
… in the “infection hypothesis” of AD. A … Hypothesis”, AD-related iron dyshomeostasis, and
the early reduced salivary lactoferrin, along with the resurrection of the Cholinergic Hypothesis