[HTML][HTML] Drug repurposing: Iron in the fire for older drugs

HV Sonaye, RY Sheikh, CA Doifode - Biomedicine & Pharmacotherapy, 2021 - Elsevier
… to as drug repurposing, drug redirecting, drug retasking, drug … (USA), defined drug repurposing
as "studying the drugs that are … indications for the existing drugs, drugs currently in clinical …

Drug Repurposing: A strategic approach to addressing unmet medical needs

G Goel - … Journal of Pharma Professional's Research (IJPPR), 2024 - ijppronline.com
… : Drug repurposing, also known as drug repositioning or drug … This review article explores
the concept of drug repurposing, its … indications for existing drugs. Challenges in traditional …

Inclusion of nitrofurantoin into the realm of cancer chemotherapy via biology-oriented synthesis and drug repurposing

PA Elzahhar, HA Nematalla, H Al-Koussa… - Journal of Medicinal …, 2023 - ACS Publications
… Moreover, our laboratory has succeeded in repurposing the obsolete anti-amoebic … to
merge the drug repurposing approach with the concept of “biology-oriented drug synthesis” (BIODS…

The updated landscape of tumor microenvironment and drug repurposing

MZ Jin, WL Jin - Signal transduction and targeted therapy, 2020 - nature.com
Drug repurposing in cancer The appeal of drug repurposing in cancer is increasing for … ,
etc.) of developing a new drug; (2) it reduces the failure risk of clinical trials because those these …

Drug repurposing in cancer therapy: influence of patient's genetic background in breast cancer treatment

R Rodrigues, D Duarte, N Vale - International journal of molecular …, 2022 - mdpi.com
drug repurposingdrug repurposing as a new window of opportunity for cancer therapy,
and specifically its application for precision medicine. We next selected some repurposed drugs

Eltrombopag inhibits the proliferation of Ewing sarcoma cells via iron chelation and impaired DNA replication

T Waters, KL Goss, SL Koppenhafer, WW Terry… - BMC cancer, 2020 - Springer
drug repurposing screen, which includes 12 Ewing sarcoma cell lines, to identify drugs that
… of eltrombopag is due, in part, to the iron chelation properties of the drug [12,13,14]. Moreover…

Exploring the Use of Intracellular Chelation and Non-Iron Metals to Program Ferroptosis for Anticancer Application

O Claudio-Ares, J Luciano-Rodríguez… - Inorganics, 2024 - mdpi.com
… of cancers to these drugs and the lack of specificity of the drugs for targeting cancer cells …
avenues for drug design. Evidence shows that ferroptosis, a relatively recently discovered iron-…

Morphological cell profiling of SARS-CoV-2 infection identifies drug repurposing candidates for COVID-19

C Mirabelli, JW Wotring, CJ Zhang… - Proceedings of the …, 2021 - National Acad Sciences
… ), N-protein image in the same area with “fire” false color LUT showing distinct morphologies
of … To rule out iron chelation as a potential mode of action, iron-saturated hololactoferrin and …

[图书][B] Computational Methods in Drug Discovery and Repurposing for Cancer Therapy

GP Nagaraju, V Amouda, AD Rao - 2023 - books.google.com
… The second set of review articles discusses important drug repurposing strategies that … drug
repurposing methods. The principles of computational drug designing and drug repurposing

[图书][B] Application of Oxygenase Enzymes for Chemoenzymatic Synthesis of Natural Products & Exploration of Iron (II) α-Ketoglutarate Sequence Space for Non …

E King-Smith - 2022 - search.proquest.com
… the heirloom dining room table on fire distilling alcohol, youГve wo@… We show how an iron(ii)
ɑY@etoglutarate (Fe(ii)/ɑKG) lYlysine … We then repurpose enzymes from the platensimycin …