Old drugs, new indications

II Miroshnichenko, EA Valdman… - Drug development & …, 2023 - pharmjournal.ru
… There are examples of successful repurposing and negative side effects with off-label drug
use, … in drug repurposing has grown markedly. A search for the keywords «drug repurposing» …

Vaporization, bioactive formulations and a marine natural product: different perspectives on antivirals

TJ Manning, J Thomas-Richardson, M Cowan… - Drug Discovery …, 2020 - Elsevier
… Simple marine creatures, such as fire coral, use complex … First- and second-line antibiotics
were repurposed attacking … used a similar repurposing approach with cancer drugs using …

Is ferroptosis a key component of the process leading to multiorgan damage in COVID-19?

AM Fratta Pasini, C Stranieri, D Girelli, F Busti… - Antioxidants, 2021 - mdpi.com
iron fluxing through the serum iron pool is determined by the rate of iron uptake by cells and
the rate of cellular iron … it is oxidized by multi-copper iron oxidase hephaestin to ferric ion (Fe …

Contemporary developments in ferrocene chemistry: physical, chemical, biological and industrial aspects

U Rauf, G Shabir, S Bukhari, F Albericio, A Saeed - Molecules, 2023 - mdpi.com
… cyclopentadienyl rings bound to a central iron atom. On account of … drug repurposing, Mbaba
and assistants developed novel ferrocene 1,3-benzoxazine conjugates by applying a drug

[图书][B] Acinetobacter baumannii-The Rise of a Resistant Pathogen: The Rise of a Resistant Pathogen

K Rangel, S De-Simone - 2024 - books.google.com
… Exogenous supplementation of iron to the wound site … , drug repurposing allows researchers
to tap into a vast library of already approved drugs, saving time and resources in drug

Bioinformatics accelerates the major tetrad: a real boost for the pharmaceutical industry

T Behl, I Kaur, A Sehgal, S Singh, S Bhatia… - International Journal of …, 2021 - mdpi.com
… a black hole due to deficiency of iron. Detailed study of … drug repurposing and 3D modeling,
where the former deals with discovering the applications and roles of already-available drugs

Erastin, a ferroptosis-inducing agent, sensitized cancer cells to X-ray irradiation via glutathione starvation in vitro and in vivo

Y Shibata, H Yasui, K Higashikawa, N Miyamoto… - PloS one, 2019 - journals.plos.org
… , iron homeostasis is often disrupted in cancer cells, which leads to excessive iron accumulation
[7], partially because that iron … the iron-dependent enzyme ribonucleotide reductase [8]. …

[图书][B] Network-based Methods for the Elucidation of Disease and Drug Mechanisms

L Han - 2019 - search.proquest.com
… approach for modeling drug effects for drug repurposing and for optimizing treatment strategies
in complex dis- ease. My approach is based on modeling drugs and genes in a network, …

Artificial Intelligence in Computer-Aided Drug Design (CADD) Tools for the Finding of Potent Biologically Active Small Molecules

B Siddiqui, CS Yadav, M Akil, M Faiyyaz… - Available at SSRN … - papers.ssrn.com
… , repurposed drugs may also receive regulatory approval more quickly and easily. Drug
repurposing may … new targets for already-known pharmaceuticals or testing established drugs for …

The Development of Metallohydroxamates as Novel Anti-Bacterial and Anti-Leishmanial Agents

D Keogan - 2018 - repository.rcsi.com
… increased interest in repurposing and repositioning of previously developed drugs as effective
… Gallium’s similarities to iron allows for its incorporation into certain iron binding proteins, …