… network to render their functional roles. In this study, we construct systematic models for the
insulin signaling network mediated by IRS 1 and IRS 2 … models of insulin signaling pathways. …

… tightly regulated signalling network comprised of intracellular signalling cascades activated
… kinase receptors for insulin and IGF-1, the insulin receptor (IR) and the IGF-1 receptor (IGF1R…

… smaller that IRS-l and IRS-2, but they contain many similar features… investigated insulin
responses in various tissues of the IRS 1(… in interleukin 4 and insulin signalling pathways in factor …

… the insulin receptor substrate (IRS)-proteins (IRS-1 and IRS-2… IRS-1 was discovered as a
substrate for the insulin receptor, … the details of the signalling pathways, we begin to appreciate …

… insulin receptor IRS-1 and IRS-2 have indicated that IRS-1 plays a major role in skeletal
muscle and adipose tissue and IRS-2 … proteins may regulate selective signaling pathways as a …

… In contrast, only negative effects on insulin signalling (red-filled circles) are observed by
phosphorylation of IRS1 by heterologous (non-insulin) signalling pathways. In some studies, …

… the insulin receptor substrate protein IRS1 lack any significant phenotype, whereas homozygous
disruption of the IRS1 gene results in a mild form of insulin … for both IRS1 and IRS2 have …

… , insulin signals are produced or modulated through tyrosine phosphorylation of IRS1 or its
homolog IRS2, … dyslipidemia in obese rodents by sensitizing insulin signaling pathways (18). …

… IGF1 and insulin signaling, the adaptor proteins Irs1 and Irs2 … show that insulin-like signals
mediated by Irs1 and Irs2 are … activating Akt→mTOR signaling and limiting AMPK activation. …

… the insulin receptor or the IGF1 receptor mediates signals primarily via the cytoplasmic proteins
IRS1 and IRS2… Activation of intracellular signaling pathways by insulin. There are 2 main …