… of isavuconazole against Aspergillus species. The best activity was seen for the combination
of tacrolimus with isavuconazole… The combination was active against all the tested species, …

… Isavuconazole is active in vitro against common Aspergillus spp., including Aspergillus
fumigatus and Aspergillus … 50% reduction in tacrolimus dose when used in combination with …

… for use in invasive aspergillosis and Mucormycosis; it also … of tacrolimus were measured
during and after isavuconazole prophylaxis. The study authors found that the median tacrolimus …

Objectives To evaluate the in vitro interactions of isavuconazole with immune suppressors (tacrolimus,
cyclosporin A or sirolimus) against 30 Mucorales isolates belonging to the most …

… of invasive aspergillosis and mucormycosis. A … aspergillosis found isavuconazole noninferior
to voriconazole. A separate, open-label study evaluating the efficacy of isavuconazole in …

… Aspergillus. Isavuconazole also has excellent in vitro activity against most Aspergillus
species, including those that are common causes of infections in humans (ie, A. fumigatus, A. …

… Citation3,Citation9 Exposure to tacrolimus was … that isavuconazole had a primary fungicidal
activity (presenting MFC within two dilutions of the MIC) against all four Aspergillus species. …

… Isavuconazole appears to have potent in vitro activity against the most common Aspergillus
species… variable extent the metabolism of sirolimus, tacrolimus, and cyclosporine, which can …

… prodrug of isavuconazole (hereafter referred to as isavuconazole … isavuconazole,13 although
FDA prescribing information only mentions an approximately 2-fold increase of tacrolimus …

… with the antifungal isavuconazole (ISA). By calculating the tacrolimus concentration/dose
(C/D) ratio… is low, 3 whereas after engraftment the risk of invasive aspergillosis is much greater. …