… Pharmacological inhibitors of p38 suppress inflammation and are … p38 activation in the
heart. The purpose is to evaluate p38 inhibition as a potential therapy for ischaemic heart …

The p38-MAPK pathway plays an important role in myocardial ischaemia/reperfusion injury
and has been … The activation of p38-MAPK by dual phosphorylation during myocardial …

… an increase in p38 MAPK activation during sustained ischaemia, similar to … p38 MAPK
activation during sustained ischaemia of both ischaemic and β-adrenergic preconditioned hearts …

… during sustained ischaemia in comparison with the controls. In conclusion the activation of
p38 MAPK during lethal ischaemia, but not during the ischaemic preconditioning protocol, is …

… of p38 MAPK protects the heart against ischaemic damage.In fact, p38 MAPK activation has
… , indicates that its activation is indeed detrimental to the ischaemic heart. This seems logical …

… show that, early in ischaemia (7.5 min), p38-MAPK dual phosphorylation is greater in autolytic
ischaemic hearts compared with index ischaemic hearts. In both groups, p38-MAPK dual …

… To test whether the phosphorylation of p38 MAPK could be the site of the blockade of
genistein, we activated p38 MAPK with anisomycin and tested whether genistein could block the …

… is often associated with the onset of heart failure. This study investigated the role of p38 MAP
kinase isoforms in the regulation of … failure secondary to ischaemic heart disease. J. Mol. …

… However, whether p38 MAPK inhibition during ischemia or reperfusion provides … We tested
the hypothesis that p38 MAPK inhibition at different times during I/R protects the heart from …

… activated p38 family member. However, understanding remains limited of how the different
p38 … In this review, we summarize current knowledge of p38 function in the heart and discuss …