… disease, including those affecting the heart and vasculature. p38 MAPK inhibitors as a
prospective … information on the p38 MAPK family, discusses the isoforms of p38 and subsequently …

… Our data from MKK6bE transgenic hearts showed that activation of p38 MAP kinase resulted
in an ≈3-fold increase in cardiac TNFα mRNA. Several transcription factors involved in …

… is often associated with the onset of heart failure. This study investigated the role of p38 MAP
kinase isoforms in the regulation of … failure secondary to ischaemic heart disease. J. Mol. …

… homogenates of ischemic hearts but not TNF-exposed hearts, p38-MAPK was associated with
… TAB1 was only strongly associated with p38 MAP kinase in peroxynitrite- and anisomycin-…

… is also activated by ischemia, although that the activation of this kinase is protective or
deleterious to the ischemic heart is still a subject of controversy. We here reasoned that acidifi…

… To assess the effect of p38 MAPK inhibition, we administered a synthetic p38 MAPK inhibitor,
SD-282, 1 day before ANG II treatment (n = 16) via gastric gavage at a dose of 60 mg/kg, …

… in p38 MAP kinase phosphorylation during ischemia per se has been described in several
[1–3] but not all studies (for review see [4,5]). The p38 MAP kinase … preconditioned hearts only …

… Globally ischaemic hearts were subsequently reper- … suggested that activation of p38 MAPK
contributes to the triggering of ischaemic preconditioning. p38 MAPK activation as mediator …

… Using the isolated perfused rat heart, we show that global … of MAPKs but rather stimulates
a 38-kD activator of MAPK-… MAPK pathways may be important in the responses of hearts …

… p42/p44-MAPK, while no additional p38 activation was seen … concept that p38 activation is
harmful to the ischaemic heart [… (α and β) expressed in the heart [39], which appear to mediate …