Involvement of p38 MAPK and JNK in heat stress-induced cardioprotection

C Pantos, V Malliopoulou, I Mourouzis… - Basic research in …, 2003 - Springer
… of phosphorylated p38 MAPK in untreated hearts (CON) and hearts from preheated rats (HS…
of activation of p38 MAPK and JNK in response to ischaemia and reperfusion after heat …

Inhibition of p38 MAPK α/β reduces ischemic injury and does not block protective effects of preconditioning

S Schneider, W Chen, J Hou… - … Physiology-Heart …, 2001 - journals.physiology.org
… in a single species and model, the isolated perfused rat heart. We find that in rat hearts,
inhibition of p38 MAPK α/β is protective, and that the addition of a p38 MAPK α/β inhibitor during …

Role of p38 inhibition in cardiac ischemia/reperfusion injury

S Kumphune, S Chattipakorn… - European journal of clinical …, 2012 - Springer
… In this review, the outcomes from studies investigating the effect of p38 inhibitors on the heart
… The p38 MAPK is a family of serine/threonine protein kinases that plays an important role in …

Sustained activation of p42/p44 mitogen-activated protein kinase during recovery from simulated ischaemia mediates adaptive cytoprotection in cardiomyocytes

A Punn, JW Mockridge, S FAROOQUI… - Biochemical …, 2000 - portlandpress.com
… role of different p38MAPK isoforms in the heart requires further … of p38-MAPK during
ischaemia in the heart may be detrimental [18,19], whereas others have suggested that p38-MAPK

Stimulation of the stress-activated mitogen-activated protein kinase subfamilies in perfused heart: p38/RK mitogen-activated protein kinases and c-Jun N-terminal …

MA Bogoyevitch, J Gillespie-Brown… - Circulation …, 1996 - Am Heart Assoc
… Using the isolated perfused rat heart, we show that global … of MAPKs but rather stimulates
a 38-kD activator of MAPK-… MAPK pathways may be important in the responses of hearts

Role of phasic dynamism of p38 mitogen-activated protein kinase activation in ischemic preconditioning of the canine heart

S Sanada, M Kitakaze, PJ Papst, K Hatanaka… - Circulation …, 2001 - Am Heart Assoc
… of the selective inhibitor of p38 MAPK, SB203580 (SB), on infarct size, p38 MAPK activity,
and HSP27 activation during or after IP using an in vivo infarction model of the canine heart. …

The relationship between p38 mitogen-activated protein kinase and AMP-activated protein kinase during myocardial ischemia

S Jacquet, E Zarrinpashneh, A Chavey… - Cardiovascular …, 2007 - academic.oup.com
… In the whole heart we examined AMPK and p38 MAPK activation after 10 min of no-flow
ischemia (Fig. 1C), a time point of reproducible activation in this model. [5] Reflecting findings …

p38 mitogen‐activated protein kinase (MAPK) is activated by noradrenaline and serves a cardioprotective role, whereas adrenaline induces p38 MAPK …

MYC Tsang, SW Rabkin - Clinical and Experimental …, 2009 - Wiley Online Library
… –reperfusion injury, acute myocardial infarction and heart failure. In contrast, some … p38
MAPK in mediating ischaemic preconditioning. The outcome of p38 MAPK activation in the heart

Tumor necrosis factor-induced protection of the murine heart is independent of p38-MAPK activation

M Tanno, DA Gorog, M Bellahcene, X Cao… - Journal of molecular and …, 2003 - Elsevier
… of myocardial p38-MAPK phosphorylation, as measured by dual phosphorylated p38-MAPK, …
However, phosphorylation of p38-MAPK at 10 min of ischemia was similar among groups (…

Diverse mechanisms of myocardial p38 mitogen-activated protein kinase activation: evidence for MKK-independent activation by a TAB1-associated mechanism …

M Tanno, R Bassi, DA Gorog, AT Saurin… - Circulation …, 2003 - Am Heart Assoc
… homogenates of ischemic hearts but not TNF-exposed hearts, p38-MAPK was associated with
… TAB1 was only strongly associated with p38 MAP kinase in peroxynitrite- and anisomycin-…