… (2, 22, 35), we examined in the present study whether p38 MAPK … evidence that activation
of p38 MAPK abolishes insulin-… In rat hearts subjected to 20 min of global ischemia, MAPK-…

… disease, including those affecting the heart and vasculature. p38 MAPK inhibitors as a
prospective … information on the p38 MAPK family, discusses the isoforms of p38 and subsequently …

… ischemic heart. The p38 MAPKs are clear examples of this. p38s are members of the
stress-activated protein kinase family [2] and are activated by various stresses including I/R in the …

… rabbit, 21 dog, 17 and pig 22 hearts. These findings are contradicted by other observations
… of p38 MAPK activation in ischaemia or IPC of the heart. Similar to p38, the ERK1/2 MAPKs …

… p38-MAPK activation in the insulin resistant heart, as well as the effects of anti-diabetic drugs
on the myocardial p38-MAPK … the utilization of a p38-MAPK inhibitor in diabetes patients to …

… role of the p38 mitogen-activated protein kinase (p38 MAPK) and Hsp27 … p38 MAPK catalytic
activity using an in vitro kinase assay. This showed an almost 7-fold increase in p38 MAPK …

… of three subfamilies of MAPKs (ERK, JNKs and p38-MAPK) by … Moreover, post-ischaemic
peroxidation of endoplasmic reticulum … of p38 MAP kinase during hypoxia in cardiomyocytes. …

… ischaemia–reperfusion injury through their effects on apoptotic cell death, such as p38 and
JNK MAPK… are routinely used to treat chronic ischaemic heart disease provide any benefit if …

… , attached to a recirculating Langendorff Gel kinase assays have shown p38 MAPK ac-
apparatus and perfused at 37C with a nominally tivation during ischemia in rat and swine hearts …

… demonstrated as percentage of total p38) (IR alone, [n = 6]: 81.5 ± 5.2% vs … p38 MAPK in
all groups, but increased phosphorylation of p38 MAPK and MAPKAPK2 in the IR alone hearts (…