Histone acetylation and DNA methylation in ischemia/reperfusion injury

J Tang, S Zhuang - Clinical Science, 2019 - portlandpress.com
… I/R injury induced the release of HDAC11, which enhanced the acetylation of histone H3 [17]. …
[17] confirmed that binding of HDAC11 to the promoter region of PAI-1 was released by I/R …

Interferon regulatory factor 1 mediates acetylation and release of high mobility group box 1 from hepatocytes during murine liver ischemia-reperfusion injury

R Dhupar, JR Klune, J Evankovich, J Cardinal… - Shock, 2011 - journals.lww.com
… for HMGB1 release during ischemic liver injury. … the acetylation status and subsequent
release of HMGB1 through histone acetyltransferases. We found that serum HMGB1 is acetylated

High mobility group box 1 release from hepatocytes during ischemia and reperfusion injury is mediated by decreased histone deacetylase activity

J Evankovich, SW Cho, R Zhang, J Cardinal… - Journal of Biological …, 2010 - ASBMB
released following liver I/R in vivo is acetylated, and that hepatocytes exposed to oxidative
stress in vitro also released acetylated … that remove acetyl groups and control the acetylation

[HTML][HTML] … monoxide potently prevents ischemia-induced high-mobility group box 1 translocation and release and protects against lethal renal ischemiareperfusion …

Y Ruan, L Wang, Y Zhao, Y Yao, S Chen, J Li, H Guo… - Kidney international, 2014 - Elsevier
acetylation and release of HMGB1 during hypoxic culture of primary mouse renal tubular
epithelia cells in vitro. Using the same renal ischemiareperfusionischemiareperfusion injury. …

[PDF][PDF] Carbon monoxide ameliorates hepatic ischemia/reperfusion injury via sirtuin 1‐mediated deacetylation of high‐mobility group box 1 in rats

J Sun, E Guo, J Yang, Y Yang, S Liu, J Hu… - Liver …, 2017 - Wiley Online Library
… (11) Recent studies have demonstrated that HMGB1 is acetylated and released from
hepatocytes and neuronal cells during IRI, which is associated with the decreased activity of …

The acetylation of RelA in Lys310 dictates the NF-κB-dependent response in post-ischemic injury

A Lanzillotta, I Sarnico, R Ingrassia, F Boroni… - Cell death & …, 2010 - nature.com
… β-amyloid-induced release of neurotoxic factors from microglial cells. However, the role of
RelA acetylation in NF-κB-mediated neuronal injury during brain ischemia remains elusive. …

Role of epigenetic regulation in myocardial ischemia/reperfusion injury

K Wang, Y Li, T Qiang, J Chen, X Wang - Pharmacological Research, 2021 - Elsevier
… and acetylation. Therefore, this review summarized the relationship and regulatory mechanism
of histone methylation and acetylation … Jiuxin pills promoted the release of exosomes from …

Histone deacetylase inhibition blunts ischemia/reperfusion injury by inducing cardiomyocyte autophagy

M Xie, Y Kong, W Tan, H May, PK Battiprolu… - Circulation, 2014 - Am Heart Assoc
acetylation of ε-amino groups on lysine residues. Appreciated first in the case of histone
proteins, where acetylation … For I/R, the ligation was released after 45 minutes of ischemia, and …

SIRT3 deficiency exacerbates ischemia-reperfusion injury: implication for aged hearts

GA Porter, WR Urciuoli, PS Brookes… - American Journal of …, 2014 - journals.physiology.org
… simulated ischemia, followed by 2 h of reperfusion. Figure 1B demonstrates that LDH release
, 55); thus we analyzed protein acetylation in mitochondrial samples isolated from WT adult, …

Inhibition of myocardial reperfusion injury by ischemic postconditioning requires sirtuin 3-mediated deacetylation of cyclophilin D

T Bochaton, C Crola-Da-Silva, B Pillot… - Journal of molecular and …, 2015 - Elsevier
… that the increased acetylation of CyPD following myocardial ischemiareperfusion facilitates
… + /NADH depletion during reperfusion is partly due to PTP opening leading to a release of …