Targeting reactive nitrogen species: a promising therapeutic strategy for cerebral ischemia-reperfusion injury

X Chen, H Chen, M Xu, J Shen - Acta Pharmacologica Sinica, 2013 - nature.com
… play a role in the process of cerebral ischemia reperfusion injury. Two major classes of free
release of dopamine in the central nervous system 10 . However, ischemia and reperfusion

[HTML][HTML] HDAC3 inhibition ameliorates ischemia/reperfusion-induced brain injury by regulating the microglial cGAS-STING pathway

Y Liao, J Cheng, X Kong, S Li, X Li, M Zhang… - Theranostics, 2020 - ncbi.nlm.nih.gov
… Taken together, we argue that acetylation of p65 at K122 … in ischemic/reperfusion-induced
neuroinflammation and brain injury. Briefly, mtDNA released from dead cells in the ischemic

Protective effects of melatonin against ischemia-reperfusion injury in the isolated rat heart

C Lagneux, M Joyeux, P Demenge, C Ribuot… - Life Sciences, 2000 - Elsevier
… Melatonin, 5-methoxy-N-acetyl-tryptamine, is a pineal hormone, released … to the
release of reactive oxygen species. In this context, melatonin is protective against ischemiareperfusion

Decreased expression of sirtuin 6 is associated with release of high mobility group box-1 after cerebral ischemia

OH Lee, J Kim, JM Kim, H Lee, EH Kim, SK Bae… - Biochemical and …, 2013 - Elsevier
… cells showed that ischemia reduced SIRT6 expression and induced the release of high …
SIRT6 siRNA dramatically enhanced the OGD-induced release of HMGB1 in SH-SY5Y cells…

Melatonin receptor‐mediated protection against myocardial ischemia/reperfusion injury: role of SIRT 1

L Yu, Y Sun, L Cheng, Z Jin, Y Yang… - Journal of pineal …, 2014 - Wiley Online Library
… After 30 min of ischemia, the slipknot was released, and the myocardium was reperfused for
… SIRT1 regulates the acetylation level of FOXO1 to affect apoptotic pathways in the heart. For …

Suppression of excessive histone deacetylases activity in diabetic hearts attenuates myocardial ischemia/reperfusion injury via mitochondria apoptosis pathway

Y Wu, Y Leng, Q Meng, R Xue, B Zhao… - Journal of diabetes …, 2017 - Wiley Online Library
acetyl transferases (HATs) regulated global acetylation … and mainly function through
acetylation/deacetylation of histone … of ischemia, the slipknot was released to perform reperfusion

Comparison of the effect of propofol and N-acetyl cysteine in preventing ischaemia–reperfusion injury

E Erturk, B Cekic, S Geze, M Kosucu… - European Journal of …, 2009 - journals.lww.com
… of the ischaemic tissues, we observed significant decreases in pH after tourniquet release
in group C. Simultaneously HCO 3 and base excess decreased in group C. Moreover, these …

Protective Effect of N-Acetylserotonin against Acute Hepatic Ischemia-Reperfusion Injury in Mice

S Yu, J Zheng, Z Jiang, C Shi, J Li, X Du… - International Journal of …, 2013 - mdpi.com
… formed from 5-hydroxytryptamine via acetylation in the pineal gland cells, and it … release is
one of the earliest and most important features of tissue injury after ischemic organ reperfusion

Effects of heparin and N-acetyl heparin on ischemia/reperfusion-induced alterations in myocardial function in the rabbit isolated heart.

GS Friedrichs, KS Kilgore, PJ Manley… - Circulation …, 1994 - Am Heart Assoc
… Although creatine kinase release occurredin the hearts from each of the two treatment … the
reperfusion period, the release of creatine kinase was less in the hearts from N-acetyl heparin-…

Complement mediators in ischemiareperfusion injury

TV Arumugam, T Magnus, TM Woodruff, LM Proctor… - Clinica Chimica …, 2006 - Elsevier
… Complement activation leads to the release of biologically active potent inflammatory …
The acetylated form of this compound, AcF-[OP(D-Cha)WR], showed the best antagonist …