… In the mammalian system, there are eight major classes of semaphorins based on structure
… for semaphorins are the so-called plexins. There are four subfamilies of vertebrate plexins ( 1 …

… In pre-clinical rat models, we show that the semaphorin-plexin pathway represents a new …
The effect of curcumin on acute kidney injury was associated with the semaphorin-plexin …

… We found that the functional inhibition of Plexin C1 in wild-type mice treated with an anti-Plexin
C1 antibody and a Semaphorin 7A peptide reduced hepatic ischemia-reperfusion injury, …

… promising therapeutic tool in ischemic stroke. In this review, we focus on the role of semaphorins
in NVU after ischemic stroke. … Neurophilins and plexins are semaphorin 3 receptors. For …

… stroke greatly depend on cerebral vessel perfusion and functional collateral circulation in
the ischemic area. Semaphorin 3E (Sema3E), one of the class 3 secreted semaphorins, has …

… linked semaphorins (class VII). Some promiscuity could exist, with certain semaphorins binding
to several plexin families (eg plexin… Different plexin family members may also bind to one …

… One such molecule, Semaphorin 3E (Sema3E), and its receptor, Plexin-D1, control vascular
… -Plexin-D1 signaling was involved in cerebrovascular remodeling after ischemic injury. We …

… Semaphorin encompasses various transmembrane and … , growing evidence suggests that
semaphorin also plays important … Semaphorin 7A (Sema7A) is the only class 7 semaphorin …

… sema3A receptor plexin-A1 increased slightly, whereas plexin-… not altered in response to
ischemia-reperfusion in wild-type (… of plexin-A3 was significantly downregulated after ischemia-…

… Reperfusion induced alterations in the expression of the genes associated with immune …
responses during reperfusion. Semaphorin 4D and plexin B1 levels were also downregulated. …