… -term consequences of acute p53 inhibition following renal IRI are … ischemic kidney injury
we utilized two dosing regimens of pifithrin-α to examine the long-term consequences of acute …

… acute kidney injury (AKI) is a potential complication of severe … Here, we aim to investigate
whether pifithrin-α protected … , and cell death in cisplatin and ischemic induced AKI [Citation9,…

… role in the pathological process of acute kidney injury (AKI). This study … ischemia/reperfusion
(I/R), while pifithrin-α decreased them. Renal I/R caused renal tubular epithelial damage in …

… injured tubular cells. Indeed, we previously showed that inhibition of p53 with pifithrin-α or
small interfering RNA in rat models of ischemic AKI … , the acute kidney protective effects of p53 …

… Pifithrin-α attenuates the acute kidney injury (AKI) sensitivity in Akita diabetic mice. Akita …
weight pifithrin-α or saline, and then subjected to 23 min of bilateral renal ischemia followed by …

… pifithrin-alpha after extended periods of reperfusion. When administered even 14 h after
ischemic injury, … area, an area not well reperfused after ischemic injury ( 1 ). Lack of blood flow to …

… are major inducers of apoptotic cell death after ischemic renal injury. In this setting, guanosine
and pifithrin-alpha are potent inhibitors of apoptosis and … Apoptosis in acute renal failure …

… in cisplatin-induced AKI, yet, pifithrin-α inhibites the p53 expression to attenuated renal …
administration is acute kidney injury (AKI).3 It is a urgent problem, alleviating the damage in AKI …

… of p53 by pifithrin-α suppresses ischemia-induced apoptosis by inhibiting transcriptional
activation of Bax and mitochondrial translocation of p53 ( 57 ). However, pifithrin-α is an unlikely …

… kidney diseases, such as acute kidney injury (AKI). Here we have demonstrated a dynamic
change of protein SUMOylation in ischemic … , we examined the effects of pifithrin-α, a specific …