Targeting the immune system for ischemic stroke

SR Zhang, TG Phan, CG Sobey - Trends in pharmacological sciences, 2021 - cell.com
… Acute ischemic stroke results in the activation of a series of inflammatory events, mediated …
, as well as infiltrating immune cells from the periphery. Some immune cells such as T helper (…

Rational modulation of the innate immune system for neuroprotection in ischemic stroke

D Amantea, G Micieli, C Tassorelli… - Frontiers in …, 2015 - frontiersin.org
… the immune system has been involved in ischemic tolerance… ischemic stroke should be
aimed at blocking the detrimental effects, while promoting the beneficial responses of the immune

Brain-immune interactions and ischemic stroke: clinical implications

H Kamel, C Iadecola - Archives of neurology, 2012 - jamanetwork.com
… In addition, we highlight the many gaps in our understanding of the role of the immune system
in CNS injury and examine promising avenues of future investigation. Although relevant to …

Immunological consequences of ischemic stroke

A Vogelgesang, KJ Becker… - Acta Neurologica …, 2014 - Wiley Online Library
… Recent observations have revealed that stroke also alters the function of the immune
system and vice versa: At the site of the infarct, a local inflammatory response develops that …

Aging immune system in acute ischemic stroke: a transcriptomic analysis

GP Sykes, J Kamtchum-Tatuene, S Falcione… - Stroke, 2021 - Am Heart Assoc
… The role of an aging immune system in patients with ischemic stroke … of stroke risk and
outcome. This study assessed the aging immune system in patients with acute ischemic stroke by …

Stroke and the immune system: from pathophysiology to new therapeutic strategies

R Macrez, C Ali, O Toutirais, B Le Mauff… - The Lancet …, 2011 - thelancet.com
immune-based stroke therapies. We postulate that a better understanding of the interactions
between the immune system … Pathophysiologic mechanisms of acute ischemic stroke: an …

Immune pathways in etiology, acute phase, and chronic sequelae of ischemic stroke

M Endres, MA Moro, CH Nolte, C Dames… - Circulation …, 2022 - Am Heart Assoc
… innate and adaptive immune systems influence cerebral damage cascades after ischemic
stroke. … influence both outcome after stroke and recurrence risk for further stroke. In addition, …

Inflammatory mechanisms in ischemic stroke: therapeutic approaches

SE Lakhan, A Kirchgessner, M Hofer - Journal of translational medicine, 2009 - Springer
… viability in the vicinity of the ischemic core. This review will discuss the … ischemic stroke and
potential therapeutic strategies that target neuroinflammation and the innate immune system

Immune cells in the BBB disruption after acute ischemic stroke: targets for immune therapy?

Y Qiu, C Zhang, A Chen, H Wang, Y Zhou… - Frontiers in …, 2021 - frontiersin.org
… blocks a variety of circulating leukocytes from entering the CNS and prevents CNS-specific
antigens from infiltrating into the peripheral immune system. The extravasation of peripheral …

The involvement and therapy target of immune cells after ischemic stroke

Z Jian, R Liu, X Zhu, D Smerin, Y Zhong, L Gu… - Frontiers in …, 2019 - frontiersin.org
ischemic brain injury. In this review, we will discuss the role of different immune cells after
stroke … , T cells act on neurons indirectly through the interaction with the innate immune system. …