… The kallikrein–kinin system is an ideal target linking key pathological hallmarks of ischemic
… evidence on the role of the kallikrein–kinin system in ischemic and traumatic brain damage. …

… event leading to ischaemic stroke in humans. To determine the potential protective role of
kallikrein–kinin in ischaemic stroke, we first employed a focal cerebral ischaemic rat model …

… of kallikrein after the onset of ischemic stroke protected … and cerebral infarction via a kinin
B2 receptor-mediated mechanism … study indicated that kallikrein, through the kinin B2 receptor …

… This entire mechanism is often referred to as the kallikrein–kinin system (KKS). BK and
closely related kinin peptides exert both short- and long-term effects on end organs by directly …

… We examined the potential effects of kallikrein gene transfer on cerebral cell survival and …
ischemia/reperfusion (I/R). Our results show that kallikrein/kinin protects against ischemic stroke…

… constituents of the contact-kinin system contribute to stroke development has been largely …
To evaluate the functional role of PK in acute ischemic stroke, we generated PK-deficient mice …

… tissue kallikrein–kinin system is activated in ischemic stroke. … stroke patients. The increase
in kallidin was accompanied by a slightly, but not significantly higher activity of tissue kallikrein…

… Kallikrein’s protective effects were blocked by the kinin B2 receptor antagonist icatibant.
The … protein infusion at one day after the onset of ischemic stroke reduced infarct size and …

… Activation of the kallikrein-kinin system promotes vascular leakage, inflammation, and
neurodegeneration in ischemic stroke. Inhibition of plasma kallikrein (PK) – a key component of …

… kallikrein (PKa), which further liberates the inflammatory mediator bradykinin by kallikrein-…
PKa can reciprocally activate FXII, leading to autoactivation of the contact–kinin pathway …