NLRP3 inflammasome: a promising target in ischemic stroke

L Gao, Q Dong, Z Song, F Shen, J Shi, Y Li - Inflammation Research, 2017 - Springer
… mechanism that directs NLRP3 inflammasome activation in ischemic stroke is rudimentary.
… of NLRP3 inflammasome in ischemic stroke (Fig. 2). During the progress of cerebral ischemia

NLRP3 inflammasome in ischemic stroke: as possible therapeutic target

M Alishahi, M Farzaneh… - … Journal of Stroke, 2019 - journals.sagepub.com
… for expression and regulation of NLRP3 inflammasome during ischemic stroke, and the …
Pathogenic mechanisms following ischemic stroke Following cerebral ischemia, a cascade …

NLRP3 inflammasome as a potential treatment in ischemic stroke concomitant with diabetes

P Hong, RN Gu, FX Li, XX Xiong, WB Liang… - Journal of …, 2019 - Springer
… , which promote ischemic cell death and insulin resistance. This review summarizes recent
progress regarding the NLRP3 inflammasome as a potential treatment for ischemic stroke in …

Inhibition of NLRP3 inflammasome: a prospective target for the treatment of ischemic stroke

YS Feng, ZX Tan, MM Wang, Y Xing, F Dong… - Frontiers in Cellular …, 2020 - frontiersin.org
NLRP3 inflammasome activation during a stroke. Besides, due to the complexity of the
pathogenesis of ischemic stroke, … which the NLRP3 inflammasome targeted treatment is effective. …

NLRP3 inflammasome activation after ischemic stroke

PP Han, Y Han, XY Shen, ZK Gao, X Bi - Behavioural Brain Research, 2023 - Elsevier
… The mechanisms that activate the NLRP3 inflammasome pyroptosis signaling pathway axis
… effects on NLRP3 inflammasomes, which may present a novel approach for treating stroke. …

Inhibition of the NLRP3-inflammasome as a potential approach for neuroprotection after stroke

S Ismael, L Zhao, S Nasoohi, T Ishrat - Scientific reports, 2018 - nature.com
… with MCC950 has therapeutic potential in ischemic stroke models. Further investigations
into the therapeutic efficacy and protocols are needed to confirm whether MCC950 treatment …

[HTML][HTML] Evidence and perspective for the role of the NLRP3 inflammasome signaling pathway in ischemic stroke and its therapeutic potential

C Ma, S Liu, S Zhang, T Xu, X Yu… - International …, 2018 - spandidos-publications.com
… to ischemia reperfusion injury during ischemic stroke (13). In … of NLRP3 inflammasome, its
activation process in the ischemic … of blocking or inhibiting NLRP3 inflammasome signaling. …

Minocycline suppresses NLRP3 inflammasome activation in experimental ischemic stroke

Y Lu, G Xiao, W Luo - Neuroimmunomodulation, 2017 - karger.com
… Since NLRP3 inflammasome activation controls the maturation and release of … ischemia
stroke, we suppose that minocycline may be involved in the regulation of NLRP3 inflammasome

Focus on the role of mitochondria in NLRP3 inflammasome activation: A prospective target for the treatment of ischemic stroke

X Zhang, W Zeng, Y Zhang, Q Yu… - International …, 2022 - spandidos-publications.com
ischemic stroke. In the present review, focus was addressed on the role of mitochondria in
cerebral ischemic stroke while keeping NLRP3 inflammasome as a link. Under ischemia and …

Hypoxia inducible factor-1α (HIF-1α) mediates NLRP3 inflammasome-dependent-pyroptotic and apoptotic cell death following ischemic stroke

Q Jiang, X Geng, J Warren, EEP Cosky, S Kaura… - Neuroscience, 2020 - Elsevier
… In conclusion, HIF-1α causes cell death after ischemic stroke through activation of the NLRP3
inflammasome, and, subsequently, pyroptosis and apoptosis. These findings suggest that …