… paths to replenish beta cells in diabetes. In this review we focus on the transcription factor
networks that establish and maintain pancreatic endocrine cell identity and how they may be …

… Her major research interests include the regulation of insulin gene transcription and the
role of transcription factors in islet cell development; and gene targeting techniques in ES …

… role of transcription factors in β-cell development, and describe how these factors form a …
NeuroD1 All islet cell types Required for islet growth and proliferation. Also important for Ins …

… Key transcription factors affecting adult beta-cell development and/… islet transcription factors
involved in beta-cell function image The other well-represented class of transcription factors …

… establishing β-cell-specific insulin expression, and in the regulation of β-cell differentiation.
It was shown that MafA, a β-cell-specific member of the Maf family of transcription factors, …

… After E15.5, its expression extends to all pancreatic endocrine cells. As a transcription factor,
Pax6 can bind to the pancreatic islet cell enhancer sequence (PISCES) [54] localized in the …

… islet progenitor cells in response to injury to the pancreas, while the ability to reprogramme
islet cells using a single transcription factor… , is that transcription factors that are present during …

… islet cell types. Rfx6 is dependent on Ngn3 and acts upstream of or in parallel with NeuroD,
Pax4 and Arx transcription factors during islet cell … expressing cells of the islet lineage. Loss-…

… -endocrine cell–expressed Islet-1 (Isl1), which was demonstrated in this study to be the
primary LIM-HD transcription factor in developing and adult islet cells. Endocrine cell–specific …

… Given the crucial role that islet-enriched TFs play in islet cell identity and function, particularly
… thus hypothesized that combinations of key TFs would identify important islet cell subtypes. …