p38 and JNK MAPK pathways control the balance of apoptosis and autophagy in response to chemotherapeutic agents

X Sui, N Kong, LI Ye, W Han, J Zhou, Q Zhang, C He… - Cancer letters, 2014 - Elsevier
… and apoptosis in response to genotoxic stress. Our increased understanding of the role
of p38 and JNK MAPK pathways in regulating the balance of autophagy and apoptosis will …

Understanding MAPK signaling pathways in apoptosis

J Yue, JM López - International journal of molecular sciences, 2020 - mdpi.com
… The stress-activated JNKs and p38 MAPKs play key roles in balancing cell survival and
death in response to both extracellular and intracellular stresses (reviewed in [12]). Extensive …

Chlorpyrifos induces apoptosis in rat cortical neurons that is regulated by a balance between p38 and ERK/JNK MAP kinases

A Caughlan, K Newhouse, UK Namgung… - Toxicological …, 2004 - academic.oup.com
… Furthermore, we implicate several MAP kinase signaling pathways in chlorpyrifos-… MAP
kinase signaling pathways are involved in the regulation of chlorpyrifos-induced apoptosis, we …

Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis

Z Xia, M Dickens, J Raingeaud, RJ Davis… - Science, 1995 - science.org
… Therefore, the dynamic balance between growth factor-activated … MAP kinase signaling
pathway in apoptosis. To investigate the importance of the p38 MAP kinase pathway for apoptosis

Antagonistic control of cell fates by JNK and p38-MAPK signaling

T Wada, E Stepniak, L Hui, A Leibbrandt… - Cell Death & …, 2008 - nature.com
… , oppositely control cellular proliferation, regeneration, senescence, and oncogenic
transformation, and that qthe balance between two pathways determines cell fates in response to a …

MAPK signaling pathways in the regulation of hematopoiesis

CR Geest, PJ Coffer - Journal of leukocyte biology, 2009 - academic.oup.com
… factor in regulating the ultimate balance among expansion, survival, … JNK proteins were first
identified as kinases that were activated by a stress- and apoptosis-inducing agent, JNKs are …

… and p38 mitogen-activated protein (MAP) kinase pathways for apoptosis in human leukaemic cells stimulated by epigallocatechin-3-gallate (EGCG): a distinct pathway …

K Saeki, N Kobayashi, Y Inazawa, H Zhang… - Biochemical …, 2002 - portlandpress.com
… intracellular signalling pathways for apoptosis induced by … two apoptosis-regulating
mitogen-activated protein (MAP) kinases, namely c-Jun N-terminal kinase (JNK) and p38 MAP kinase

Integrated activation of MAP3Ks balances cell fate in response to stress

AM Winter‐Vann, GL Johnson - Journal of cellular biochemistry, 2007 - Wiley Online Library
… A transient activation of JNK or p38, for example, might have a protective effect in a cellular
… of the same MAPK might lead to a commitment to apoptosis. The concentration of the …

Inhibition of p38 MAPK sensitizes tumour cells to cisplatin‐induced apoptosis mediated by reactive oxygen species and JNK

L Pereira, A Igea, B Canovas, I Dolado… - EMBO molecular …, 2013 - embopress.org
… Since JNK signalling plays an important role in apoptosis induction (Davis, 2000), we … this
pathway was implicated in the enhanced apoptosis observed upon p38 MAPK inhibition. We …

JNK, but not MAPK, activation is associated with Fas‐mediated apoptosis in human T cells

DJ Wilson, KA Fortner, DH Lynch… - European journal of …, 1996 - Wiley Online Library
apoptosis, is blocked by increased levels of CAMP. The balance between proliferation and
apoptosis by … TCR activation of the RadRaf-l/MAPK pathway versus JNK activation by Fas. …