Signal integration by JNK and p38 MAPK pathways in cancer development

EF Wagner, ÁR Nebreda - Nature Reviews Cancer, 2009 - nature.com
pathways for tumorigenesis in various organs. The expression or activity of JNK and p38
MAPK pathway … defining the functions of the JNK and p38 MAPK pathways in different cancers. …

MAP kinase pathways activated by stress: the p38 MAPK pathway

T Obata, GE Brown, MB Yaffe - Critical care medicine, 2000 - journals.lww.com
… upstream of the JNK and p38 MAPK cascades. The p38 MAPK and JNK pathways can be
activated … negative constructs of Rac or Cdc42 inhibit p38 MAPK and JNK activation (41, 42) . …

p38 and JNK MAPK pathways control the balance of apoptosis and autophagy in response to chemotherapeutic agents

X Sui, N Kong, LI Ye, W Han, J Zhou, Q Zhang, C He… - Cancer letters, 2014 - Elsevier
p38 MAPK and JNK pathway. A number of representative up and downstream targets are
shown. Both p38 MAPK and JNK … suggested that MAPK, especially p38 MAPK and JNK, play a …

Inhibition of the p38 pathway upregulates macrophage JNK and ERK activities, and the ERK, JNK, and p38 MAP kinase pathways are reprogrammed during …

JP Hall, RJ Davis - Journal of cellular biochemistry, 2002 - Wiley Online Library
… In the present work, we demonstrate that JNK, ERK, and p38 MAP kinase activities are
reprogrammed during the IL-6-induced, macrophage-like differentiation of the murine myeloid M1 …

Regulation of JNK and p38 MAPK in the immune system: signal integration, propagation and termination

G Huang, LZ Shi, H Chi - Cytokine, 2009 - Elsevier
… components of the MAPK pathway that facilitate the activation and propagation of MAPK
signaling in immune responses. Moreover, MAPK activity is negatively regulated by MAPK

The p38 MAP kinase pathway and its biological function

L New, J Han - Trends in cardiovascular medicine, 1998 - Elsevier
… Thus, the p38 MAP kinase cascade may consist of the sequence: MEKK5’… JNK pathway
plays a role in upregulating the gene expression. As already mentioned here, the p38 pathway

[HTML][HTML] Antagonistic control of cell fates by JNK and p38-MAPK signaling

T Wada, E Stepniak, L Hui, A Leibbrandt… - Cell Death & …, 2008 - nature.com
… Here we report that JNK and p38-MAPK pathways antagonistically control cellular
senescence, oncogenic transformation, and proliferation in primary mouse embryonic fibroblasts (…

Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases

GL Johnson, R Lapadat - Science, 2002 - science.org
… The c-Jun amino-terminal kinases (JNKs) are critical regulators of transcription, and JNK
inhibitors may be effective in control of rheumatoid arthritis. The p38 MAPKs are activated by …

[HTML][HTML] Sustained activation of JNK/p38 MAPK pathways in response to cisplatin leads to Fas ligand induction and cell death in ovarian carcinoma cells

A Mansouri, LD Ridgway, AL Korapati, Q Zhang… - Journal of Biological …, 2003 - ASBMB
… of the JNK/p38 MAPK pathways by … JNK > c-Jun > FasL > Fas pathway plays an important
role in mediating cisplatin-induced apoptosis in ovarian cancer cells, and the duration of JNK

Mixed-lineage kinase control of JNK and p38 MAPK pathways

KA Gallo, GL Johnson - Nature reviews Molecular cell biology, 2002 - nature.com
… All the MLK family members have been shown to activate the JNK pathway. MLK3 and dual-…
the p38 MAPK pathway, but it is not known whether other MLKs can also activate p38. The …