TGFβ regulation of epithelial cell proliferation

HL Moses - Molecular reproduction and development, 1992 - Wiley Online Library
… by TGF-P, we used extracts from mouse keratinocytes that had … TGF-(3 is an important
negative regulator of cell proliferation. … regulator such as TGF-a, negative regulation by TGF-P …

Role of TGF-β in skin chronic wounds: a keratinocyte perspective

S Liarte, Á Bernabé-García, FJ Nicolás - Cells, 2020 - mdpi.com
… double-peak dynamics mentioned earlier [35] as well as with the evidence indicating that
after injury, initial keratinocyte proliferation is restricted to cells distal to the leading edge, with …

Regulation of keratinocyte function by growth factors

K Hashimoto - Journal of dermatological science, 2000 - Elsevier
… The most important growth factors for normal human keratinocyte proliferation are members
… We studied the effect of TGF-β1 on SMADs expression in keratinocytes by RNAase …

Effect of TGF-β1 on re-epithelialization of human keratinocytes in vitro: an organotypic model

JA Garlick, LB Taichman - Journal of investigative dermatology, 1994 - Elsevier
Transforming growth factor beta-t (TGF-ftt) has been shown to inhibit keratinocyte proliferation
… To explore this apparent paradox, the effect of TGF-fit on proliferation and migration was …

Altered Regulation of TGFβ1 and TGF‐α in Primary Keratinocytes and Papillomas Expressing v‐Ha‐ras

AB Glick, MB Sporn, SH Yuspa - Molecular carcinogenesis, 1991 - Wiley Online Library
… that primary mouse keratinocytes produce TGF-p2 following the … TGF-p and TGF-a in vitro
and in vivo in primary keratinocytes … in the control of keratinocyte proliferation. In response to …

Vimentin coordinates fibroblast proliferation and keratinocyte differentiation in wound healing via TGF-β–Slug signaling

F Cheng, Y Shen… - Proceedings of the …, 2016 - National Acad Sciences
… the transdifferentiation of keratinocytes, reviving … proliferation, TGF-β1–Slug signaling,
collagen accumulation, and EMT processing, all of which in turn govern the required keratinocyte

TGF-β1 stimulates expression of keratinocyte integrins during re-epithelialization of cutaneous wounds

J Gailit, RAF Clark, MP Welch - Journal of Investigative Dermatology, 1994 - Elsevier
TGF-fJl might stimulate the expression of as and av, we investigated the effect of TGF-/11 on
cultured human keratinocytes… , av, /11, and /15 after treatment with TGF-/11. Stimulation with …

Enhanced keratinocyte proliferation and migration in co-culture with fibroblasts

Z Wang, Y Wang, F Farhangfar, M Zimmer, Y Zhang - PloS one, 2012 - journals.plos.org
… but could still produce higher level of HB EGF with IL1α or/and TGF β 2 stimulations, in
which HB EGF levels were higher than non-stimulation but lower than non-irradiated cells with …

Transforming growth factor beta 1 suppression of c-myc gene transcription: role in inhibition of keratinocyte proliferation.

JA Pietenpol, JT Holt, RW Stein… - Proceedings of the …, 1990 - National Acad Sciences
… In a similar manner as reported in this study, TGF-,31 may down-regulate other
proliferationassociated genes that may be involved in regulating c-myc. In a second model, TGF-t1 …

Human skin keratinocytes on sustained TGF-β stimulation reveal partial EMT features and weaken growth arrest responses

S Liarte, Á Bernabé-García, FJ Nicolás - Cells, 2020 - mdpi.com
… Competent keratinocyte proliferation and migration constitute a necessary requisite for
successful re-epithelization and wound closure [26]. Precisely, during wound healing, …