Ketone bodies as epigenetic modifiers

HB Ruan, PA Crawford - Current Opinion in Clinical Nutrition & …, 2018 - journals.lww.com
… circulating ketone bodyketone bodies is SCOT-dependent mitochondrial terminal oxidation
in the tricarboxylic acid cycle, in this review, we explore alternative roles that ketone bodies

[HTML][HTML] Ketone bodies as metabolites and signalling molecules at the crossroad between inflammation and epigenetic control of cardiometabolic disorders

N Bendridi, A Selmi, A Balcerczyk, L Pirola - International journal of …, 2022 - mdpi.com
… endpoint effects of ketone bodies. In this review, we discuss the impact of ketone bodies on
the … as epigenetic modifiers and from the perspective of their anti-inflammatory properties. …

[HTML][HTML] Ketone bodies and SIRT1, synergic epigenetic regulators for metabolic health: a narrative review

R Tozzi, F Cipriani, D Masi, S Basciani, M Watanabe… - Nutrients, 2022 - mdpi.com
… Recent findings suggest that β-OHB coordinates cellular functions via a novel epigenetic
modification termed the β-hydroxybutyrylation, that integrates classic DNA methylation and …

Ketone bodies rescue mitochondrial dysfunction via epigenetic remodeling

J Gambardella, SS Jankauskas, U Kansakar… - Basic to Translational …, 2023 - jacc.org
… We identified a specific epigenetic modification of the chromatine, at the level of histone 3,
namely a double methylation of lysine 27 and a single methylation of lysine 36 (…

[HTML][HTML] Modulation of cellular biochemistry, epigenetics and metabolomics by ketone bodies. Implications of the ketogenic diet in the physiology of the organism and …

A Dąbek, M Wojtala, L Pirola, A Balcerczyk - Nutrients, 2020 - mdpi.com
Epigenetic modifications constitute a key element of regulation of gene transcription. Recent
… that ketone bodies coordinate cellular functions via a novel epigenetic modification—β-…

[HTML][HTML] Ketone Bodies Preserve Mitochondria Through Epigenetics

R Mukai, J Sadoshima - Basic to Translational Science, 2023 - jacc.org
… of ketone bodies during … epigenetics could broadly affect multiple gene sites in a sustained
manner, it would be interesting to clarify the salutary effect of BHB on chromatin modification

[HTML][HTML] β-Hydroxybutyrate as an epigenetic modifier: Underlying mechanisms and implications

Y He, X Cheng, T Zhou, D Li, J Peng, Y Xu, W Huang - Heliyon, 2023 - cell.com
… β-Hydroxybutyrate (BHB) is the main component of ketone bodies, constituting around 70
% of the circulating ketone body pool. Previous studies suggested that physiological doses of …

[HTML][HTML] Ketone bodies as signaling metabolites

JC Newman, E Verdin - Trends in Endocrinology & Metabolism, 2014 - cell.com
… of CR appear to be due to modification of specific nutrient-… cellular environment and the
epigenetic changes associated with … many also alter the epigenetic regulation of gene expression…

Ketotherapy as an epigenetic modifier in cancer

B Bandera-Merchan, H Boughanem… - Reviews in Endocrine …, 2020 - Springer
… Main ketone bodies are involved in different epigenetic mechanisms, which are responsible
… Previously, we commented that ketotherapy is an epigenetic modifier. Β-hydroxybutyrate is …

Acetate as a metabolic and epigenetic modifier of cancer therapy

DM Jaworski, AMA Namboodiri… - Journal of cellular …, 2016 - Wiley Online Library
… both acetate and ketone bodies can be utilized for brain energy production, bypass glycolysis,
and spare cytosolic NAD, acetate and ketone bodies are distinct in that ketone bodies, but …