… activity was localized to an extracellular Glu residue (E600) in the … key regulatory site of
the receptor by setting sensitivity to other noxious stimuli in response to changes in extracellular …

… observation, several intracellular binding sites have been identified; amino acids residues
Arg-114 in the amino-terminus and Glu-761 in the carboxy-terminus play a key role in ligand …

… In contrast to the extracellular sites for protonation, the site … in sensing and maintaining
extracellular and intracellular pH. … Further study has localised key residues that determine …

… To confirm an action at proton-binding sites, we used mutant receptors lacking acidic
extracellular amino acids identified as a key for proton activation and modulation. E600 is believed …

… ), TRPV1 is considered to be a key component of signal transduction … sites via protein
kinase C and protein kinase A downstream of activation of GTP-binding protein-coupling receptor …

… Though the capsaicin receptor is known to function as TRPV1 … to extracellular pore domain
of the channel, while capsaicin … S2 to S4 segments are key to capsaicin binding, while the …

… The capsaicin binding site has been partially localized to the intracellular loop between the
… TRPV1 and the gut: from a tasty receptor for a painful vanilloid to a key player in hyperalgesia…

… The identification of [ 3 H]-RTX binding sites on the … ages and IB4-positive neurons play a
key role in acute noxious heat … Our knowledge of intracellular signaling pathways in nociceptive …

… To confirm that the vanilloid binding site is intact, we compared [ 3 H]RTX binding in wild-…
Asp) in putative extracellular domains of VR1 were mutated demonstrated that a key glutamine …

… observations that capsaicin can activate TRPV1 from both intracellular and extracellular sides…
modeling and mutagenesis tests, it was proposed that capsaicin takes a “head-down tail-up…