… activity in patients with idiopathic membranous nephropathy (iMN). To determine the most
sensitive test for the diagnosis of PLA2R-related membranous nephropathy (MN) irrespective …

… , in which positive serology now replaces kidney biopsy and quantitative assessment of PLA2R
… , kidney biopsy samples also show IgG staining along the tubular basement membrane. …

… was confirmed by review of native kidney biopsies, when done in our institution, and/or by
review of biopsy slides or pathology reports if the original kidney biopsy was not done in our …

… the diagnostic performance of kidney biopsy. The added value of kidney biopsy was studied
by the … In these patients, the kidney biopsy did not provide significant information that altered …

… In most centers a diagnostic renal biopsy remains the standard of care, even in anti-PLA2R/THSD7A–positive
nephrotic patients. The characteristic morphologic changes in PMN are …

… We think that in patients with low risk for a biopsy, we should continue performing kidney
biopsies in centers that have developed biorepositories, making the biopsy available for next …

… Enhanced staining for THSD7A antigen was demonstrable in renal biopsy tissue.27
Unlike PLA2R, THSD7A is expressed on murine podocytes, and MN was induced in mice by …

… recorded in renal biopsy registries (Table 1) [10–15]. IgA nephropathy was the most common
primary glomerular disease in Japan. Thus, the frequency of MN in renal biopsied cases …

… Diagnosis was confirmed in all patients by percutaneous needle renal biopsy. Patients
who, … patients with idiopathic membranous nephropathy (IMN). (A) Renal survival rates in …

… These discoveries have led to the development of serologic tests, which in conjunction with
renal biopsy findings to include special IF or immunohistochemical (IHC) stains, can lead to …