… of Wnt/β-catenin signalling in mediating podocyte injury, and describes the therapeutic
potential of targeting this pathway for the treatment of proteinuric kidney disease. …

… Wnt and β-catenin activity have been localized to the proximal tubule after the ischemia-…
/β-catenin pathway is altered in human kidney disease. Transcriptomic data from human kidneys …

… during acute kidney injury and cystic kidney diseases. Additionally, WNT–β-catenin signalling
is involved in CKD-associated vascular calcification and mineral bone disease. The WNT–…

… in adult kidney has identified another oncogeni‑ cally relevant E3 ligase target: β‑catenin.
This … pathogenesis of polycystic kidney disease, where the identification of disease genes has …

… The panoply of Wnt/β-catenin effects described in this review emphasizes the challenges
to understanding the biological impact of this pathway on kidney disease. At this point, …

… of many progressive chronic diseases including chronic kidney disease, continue to increase
… /β-catenin signaling pathway is essential to embryonic development in general and kidney …

… disease conditions, including diabetic nephropathy, cystic kidney disease, and acute kidney
… Despite these observations, the pathological role played by β-catenin in kidney diseases is …

… of cystic kidney disease that do not display WNT/β-catenin … tubules is operative in certain
types of cystic kidney diseases, … role of β-catenin as a mediator of polycystic kidney disease is in …

… kidney disease (CKD) have significantly increased morbidity and mortality resulting from
infections and cardiovascular diseases. … and the Wnt/β-catenin signaling pathway was the most …

… dogma is that Wnt/β-catenin signaling promotes fibrosis and development of chronic kidney
disease (CKD). As the role of proximal tubular β-catenin signaling in CKD remains unclear, …