… kidney fibrosis development and whether inhibition of Notch activation by DBZ could ameliorate
renal fibrosis … the Notch pathway is involved in kidney fibrosis through activation of TGF-β…

… RIP may be a therapeutic target in renal fibrosis and γ-secretase inhibition has been proposed
as a … the effects of γ-secretase inhibition on albumin-induced pro-fibrotic effects in PTECs. …

… of PSEN and γ-secretase in the broader physiological context, but also provide an updated
catalogue of mutations in γ-secretase components discovered so far in human diseases. …

… kidney fibrosis. Therefore, Notch signalling has gained significance as a potential therapeutic
target in fibrosis. … Further, Notch ligand binding followed by γ-secretase-regulated cleavage …

… of this pathway is implicated in human fibrotic diseases, such as pulmonary, renal, and
peritoneal fibrosis. However, the role of Notch signaling in hepatic fibrosis has not been fully …

… renal disease. The glomerulus is the main filtration barrier that determines global kidney …
chronic kidney disease (CKD). Injury to the tubulointerstitial tissue is a major cause of acute …

… The effect of the functionalized GSIs was also determined in another experimental model of
renal disease induced by the administration of ADR. As opposed to AA which mainly induces …

… Peritoneal fibrosis, a major complication of peritoneal dialysis, limits the effectiveness of
peritoneal dialysis as a treatment of end-stage renal disease. Preventing this complication by …

… Despite all these caveats, we can conclude that γ-secretase is clearly crucial for renal …
Finally, our results have significant implications for treatment of Alzheimer's disease. As the …

… Chronic kidney disease is a leading cause of death in the … γ-Secretase inhibitors do not alter
serum creatinine decline … in AKI and fibrosis, we treated mice with γ-secretase inhibitor XX (…