Altered pharmacokinetics (PK) in subjects with chronic kidney … physiologically based
pharmacokinetic (PBPK) models of … Drug models verified using PK data from healthy subjects (…

… for kidney function during normal development, acute kidney injury, and chronic diseases.
Pharmacometric modeling … , characterize the effects of kidney function on drug exposure and …

… pharmacokinetics in patients with CKD. Physiologically based pharmacokinetic models were
… Correlation of kidney size with kidney function and anthropometric parameters in healthy …

… kidney, and L-1210 tumor cells. King and Dedrick developed a five-compartment model to
describe pentostatin pharmacokinetics … in a flow-limited model to account for tissue distribution …

… normal kidney function. Overall, the results showed that the PBPK model constructed in this
study predict the pharmacokinetic … suffering from varying degrees of impaired kidney function. …

… with impaired kidney function. In the current study, we used PBPK modeling and simulations
… and OATP1B3) in patients with impaired kidney function. Four drugs that are predominantly …

… pharmacokinetic analysis of vancomycin concentrations in 78 elderly patients. Six
pharmacokinetic models … Disease (MDRD), Chronic Kidney Disease Epidemiology Collaboration …

… of kidney function [Citation16]. The reduction in serum albumin levels has been reported
in many studies [Citation4,Citation10,Citation12,Citation20,Citation22,Citation26,Citation28,…

… based pharmacokinetic models to evaluate drug … kidney, liver, and lung are assigned to
either rapidly perfused organs or slowly perfused organs for easy presentation. Pharmacokinetic …

… The GFR of patients with near-normal kidney function was underestimated in the original …
with nearly normal kidney function. Appropriate descriptors of renal function are essential to …