… The mammalian kidney is particularly susceptible to these two kinds of acute kidney
injuries (AKIs) for several reasons. First, the mammalian kidney has no portal blood supply (unlike …

… In conclusion, much progress has been made in identifying the cell type that drives the
nephron epithelial repair responses after injury and during epithelial homeostasis. …

… , we investigated the time course for proliferative expansion of injured epithelial cells after
injury. In uninjured kidneys from … sections at baseline and at 2, 7, or 15 days after kidney injury. …

… to our understanding of repair after kidney injury, including epithelial regeneration. Here we
… cellular hierarchies and mechanisms underlying kidney injury and repair, with a particular …

… Primary tubular diseases generally display as acute kidney injury (AKI or acute renal failure),
in which the majority of affected tubules undergoes complete regeneration [6]. However, in …

… cells from kidney or urine have identified a role for kidney injury-induced epithelial cell states
… normal kidney epithelium through a process of adaptive repair, a subset of dedifferentiated …

… that govern epithelial division independent of kidney injury, … by epithelial proliferation, such
as polycystic kidney disease and … point to new therapeutic strategies to promote renal repair. …

… in which majority of tubular epithelial cells, but no interstitial cells, … /R injury to these mice
despite an extensive tubular epithelial … kidney tissue repair is through surviving tubular epithelial …

… and regenerating renal proximal tubular epithelial cells following … repair process. In the
present study, we report that expression of KIM-1 facilitates renal tubular epithelial cell repair by …

… injury phase and processes related to repair of the epithelial layer. Recent data challenge the
paradigm that epithelial-… After severe injury, the epithelial proliferative response is impaired …