An activatable near-infrared fluorescence probe for in vivo imaging of acute kidney injury by targeting phosphatidylserine and caspase-3

J Weng, Y Wang, Y Zhang, D Ye - Journal of the American …, 2021 - ACS Publications
… However, designing an imaging probe that is renal-clearable and concurrently … fluorescence
activation, we design and synthesize an activatable small-molecule NIR fluorescent probe (1…

An inherently kidney-targeting near-infrared fluorophore based probe for early detection of acute kidney injury

F Wang, X Jiang, H Xiang, N Wang, Y Zhang… - Biosensors and …, 2021 - Elsevier
… However, the noninvasive fluorescence imaging of ONOO − in the kidney is much more
challenging owing to the slow accumulation of conventional organic fluorophores in the …

Redox-reversible near-infrared fluorescent probe for imaging of acute kidney oxidative injury and remedy

Y Ding, R Zhong, R Jiang, X Yang, L He, L Yuan… - ACS …, 2023 - ACS Publications
… Herein, we report a reversible fluorescence probe, NRN, to monitor the ONOO – /GSH in
an acute kidney injury model. The NRN near-infrared fluorescent probe features a big Stokes …

[HTML][HTML] Visualization of oxidative injury in the mouse kidney using selective superoxide anion fluorescent probes

Y Lv, D Cheng, D Su, M Chen, BC Yin, L Yuan… - Chemical …, 2018 - pubs.rsc.org
… the cisplatin-induced acute kidney injury and LC remediation … probes can serve as promising
fluorescent tools for facilitate biomedical study on the roles of O 2 − in various kidney injury

Peroxynitrite activated near-infrared fluorescent probe for evaluating ferroptosis-mediated acute kidney injury

W Yang, R Liu, X Yin, Y Jin, L Wang, M Dong… - Sensors and Actuators B …, 2023 - Elsevier
… a NIR fluorescent probe to monitor … fluorescence probe (NFP-ONOO) with highly sensitive
for the real-time detection of the ONOO − in ferroptosis-mediated AKI (Scheme 1B). The probe

Kidney-Targeted Near-Infrared Fluorescence Probe Reveals That SO2 Is a Biomarker for Cisplatin-Induced Acute Kidney Injury

S Jiang, J Hong, S Gong, Q Li, G Feng - Analytical Chemistry, 2023 - ACS Publications
… , (29−31) no probe has been reported to detect SO 2 in drug-induced AKI. Herein, we report
a novel NIR fluorescent probe DSMN (Scheme 1) that can specifically target the kidneys and …

Molecular optical imaging probes for early diagnosis of drug-induced acute kidney injury

J Huang, J Li, Y Lyu, Q Miao, K Pu - Nature materials, 2019 - nature.com
… other upregulated structural proteins (kidney injury molecule-1 (… as safety biomarkers for
detection of kidney injury. In addition, … 1) is a dual-channel probe that is always fluorescent but …

Precise monitoring of drug-induced kidney injury using an endoplasmic reticulum-targetable ratiometric time-gated luminescence probe for superoxide anions

Z Tang, B Song, W Zhang, L Guo, J Yuan - Analytical chemistry, 2019 - ACS Publications
… To date, the majority of the fluorescent probes developed for O 2 •– detection were
intensity-based probes, and ER-targetable probes for O 2 •– were very limited. Besides, even though …

A lipid droplet-specific NIR fluorescent probe with a large stokes shift for in vivo visualization of polarity in contrast-induced acute kidney Injury

J Zhang, W Han, X Zhou, X Zhang, H Zhang… - Analytical …, 2023 - ACS Publications
… To synthesize a fluorescent probe sensitive to polarity, we designed a relatively long
donor−π–acceptor (D−π–A) system with a divinyl structure and endowed the probe LD-B with TICT …

Recent Progress in Molecular Probes for Imaging of Acute Kidney Injury

M Sitara, W Zhang, H Gao, J Li… - Chemical & Biomedical …, 2024 - ACS Publications
… to screen for drug-induced early kidney injury, which was not possible with traditional
diagnostic methods. Their artificially produced fluorescent probes also made it possible to identify …