… Additionally, we provide some updated potential therapeutic targets for the prevention or …
Finally, we propose mechanisms of ischemic AKI-induced liver, intestine, and kidney …

Acute kidney injury (AKI) is a common complication in critically ill patients and subsequently
worsens outcomes. Although many drugs to prevent and treat AKI have shown benefits in …

… therapeutic … kidney injury. Confirmation that any of the drugs reviewed in this paper are
safe and effective in patients with impaired kidney function will open the way to new therapeutic …

… molecules as therapeutic targets in the treatment of AKI and the AKI-CKD transition. … ,
further indicating that BMPs are promising therapeutic targets in AKI treatment. In addition, MyoR …

… kidney injury, its progression to fibrosis, or both, are examined to gain mechanistic insights
and identify potential therapeutic targets for cisplatin-induced kidney … chronic kidney injuries. …

… therapies which target miRs. Since many of the candidate therapeutic targets identified to
date in kidney … or homeostasis, design of successful therapies for CKD has been held back by …

… will be critical to deciding which therapeutic intervention to deploy. Therefore, all of the
potential therapeutic targets described below should be assessed within this framework. …

… for tissue injury in all organs, boosting of the antioxidative Keap1- Nrf-2 system by activators
of Nrf-2 or Keap-1 inhibitors seem to be the most promising therapeutic target for prevention …

… Sepsis-associated acute kidney injury (SA-AKI) is linked to high morbidity and mortality.
To date, singular approaches to target specific pathways known to contribute to the …

… of Henle located in the renal medulla, are likely to be the primary location of injury in most
forms of AKI and hence, also represent one of the most important therapeutic targets for AKI. …