Defining and redefining the nephron progenitor population

C Hendry, B Rumballe, K Moritz, MH Little - Pediatric Nephrology, 2011 - Springer
… In conclusion, our understanding of the nephron progenitor population within the
developing kidney has advanced considerably. However, the intricate interplay between this …

Nephron progenitor cells: shifting the balance of self-renewal and differentiation

R Kopan, S Chen, M Little - Current topics in developmental biology, 2014 - Elsevier
… of newly formed nephrons to regulate the formation of subsequent nephrons or the …
progenitors within the developing kidney. In this review, we will focus on the nephron progenitor

Lgr5+ ve stem/progenitor cells contribute to nephron formation during kidney development

N Barker, MB Rookmaaker, P Kujala, A Ng… - Cell reports, 2012 - cell.com
nephron formation within the developing kidney. Here, we document expression of the adult
stem cell marker Lgr5 in the developing kidney and assess the stem/progenitornephrons in …

Kidney nephron determination

L Oxburgh - Annual review of cell and developmental biology, 2018 - annualreviews.org
… of how the nephron progenitor cell population balances … committed to nephron progenitor
or stromal progenitor fates within the … to epithelial induction of nephron formation from the CM. …

Single adult kidney stem/progenitor cells reconstitute three-dimensional nephron structures in vitro

S Kitamura, H Sakurai, H Makino - Stem cells, 2015 - academic.oup.com
kidney stem/progenitor cells (KS cells), derived from the S3 segment of adult rat kidney
nephrons… We previously established kidney stem/progenitor cells (KS cells) from adult kidney in …

[HTML][HTML] The number of fetal nephron progenitor cells limits ureteric branching and adult nephron endowment

C Cebrian, N Asai, V D'Agati, F Costantini - Cell reports, 2014 - cell.com
nephron progenitor cell number, we genetically ablated 40% of these cells, asking whether
this would limit kidney size and nephron … of progenitor cells is a limiting factor during kidney

A synthetic niche for nephron progenitor cells

AC Brown, SD Muthukrishnan, L Oxburgh - Developmental cell, 2015 - cell.com
… a mixture of cells with varying progenitor potential. Furthermore, … This in vitro nephron
progenitor niche will have important … kidney develops by radial addition of new nephrons that form …

Regulation of nephron progenitor cell lifespan and nephron endowment

AJ Perl, MP Schuh, R Kopan - Nature reviews Nephrology, 2022 - nature.com
… in susceptibility to kidney disease; however, … nephron progenitor cell exhaustion, have the
potential to inform interventions to enhance nephron endowment and improve lifelong kidney

Identification of adult nephron progenitors capable of kidney regeneration in zebrafish

CQ Diep, D Ma, RC Deo, TM Holm, RW Naylor, N Arora… - Nature, 2011 - nature.com
… These findings demonstrate that lhx1a:EGFP + aggregates contain nephron progenitors
and support our observation that multiple nephron progenitors are needed to form a nephron. …

Selective in vitro propagation of nephron progenitors derived from embryos and pluripotent stem cells

S Tanigawa, A Taguchi, N Sharma, AO Perantoni… - Cell reports, 2016 - cell.com
Nephron progenitors in the embryonic kidney propagate while generating differentiated …
of nephron progenitors, which will be essential for dissecting the mechanisms of kidney