… effective disease-modifying therapies. Recently, phosphoinositide 3-kinase (PI3K) and Akt
are … role of PI3K-Akt pathway in AD and agents which may modulate Akt and have therapeutic …

… The integrated coordination of neuronal responses through the PI3-K/Akt pathway has
significant functional impact on key events that go awry in Alzheimer's disease (AD), including: …

… kinase Akt were compared in mid-temporal and mid-frontal cortices from Alzheimer's disease
cases … Activities (GSK-3α/β fusion protein phosphorylation by immunoprecipitated Akt) were …

… With the emergence of aging population, the health problem and economic burden
caused by the two diseases also increase. Phosphatidylinositol 3-kinases/protein kinase B (PI3K/AKT…

… 3-kinase-Akt may protect against neuronal cell death in Alzheimer's disease (AD). Here, …
evidence of increased Akt activation, and hyperphosphorylation of critical Akt substrates in AD …

… receptor tyrosine kinase signaling to the survival kinase AKT. … such as AKT and PDK1 to
colocalize, resulting in the kinase-… Thus, activated PI3K induces the activation of AKT, which …

… kinase, Akt/PKB, concurrent with elevated endogenous GSK3β kinase activity in familial
Alzheimer's disease β-… familial Alzheimer's disease presenilin lymphoblast cells. Further, familial …

… migrate through activation of the receptor tyrosine kinase ErbB4 (Gambarotta 2004a). Upon
… the phosphorylation of Akt, leading to the activation of this protein kinase. The results of a …

… One of the new therapeutic targets for AD is the phosphatidylinositol 3-kinase (PI3K)/AKT
pathway. In this review, questions on the two hypotheses, the definition of the PI3K/…

… Decreased levels of phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K) subunits as well
as blunted Akt kinase phosphorylation have been observed in the AD brain, characterized …