… of intrinsic resistance to EGFR TKIs in advanced NSCLC, which will help improve patient …
and develop new potential agents and therapeutic strategies to overcome this resistance. …

… resistance, with a focus on resistance to kinase inhibitors in EGF … of primary and acquired
resistance and then review … been shown to result in intrinsic resistance to EGFR TKIs in EGFR-…

… of intrinsic from acquired resistance is based … resistance” may combine the expansion of
original clones pre-existing prior to treatment (as in the “intrinsic resistance”) and new resistance …

… resistant subjects with the polymorphism subsequently did not respond to second-generation
TKI therapy (Supplementary Table 10), a finding that is in line with the intrinsic resistance …

… ) and intrinsic resistance to receptor tyrosine kinase inhibitor (… The phenomenon of intrinsic
resistance to rTKI is not well … aimed to characterize patients with intrinsic resistance to rTKI …

… resistance to kinase inhibitors has … of intrinsic resistance to RAF inhibitors will be likely be
diverse. The PI3K pathway appears to play a key role in intrinsic resistance to RAF inhibitors. …

… cell apoptosis that induced by kinase inhibitor 33,34 . Germline … , leading to intrinsic resistance
in kinase inhibitor therapy 15,35 … cause of intrinsic resistance to kinase inhibitor therapy in …

… of the cytoplasmic tyrosine kinase domain, which, with the aid of … Tyrosine kinase inhibitors
(TKIs) have been used to treat the … was sufficient to confer intrinsic TKI resistance in chronic …

… in the absence of oncogenic kinase signaling, a phenomenon referred to as intrinsic
resistance, depends on diverse growth factors. Here we report that oncogenic kinase and growth-…

… tyrosine kinases functions as a mechanism of intrinsic resistance … Of the patients with
acquired resistance to EGFR TKI … to previously-defined acquired resistance mutations in Abl, …