… to EGFR-TKIs is inevitable due to various mechanisms, such as … and summarize the known
resistant mechanisms to EGFR-… We review and summarize the known resistant mechanisms …

… of TKI resistance in CML. In this review, we present molecular mechanisms of TKI resistance
paying particular attention to drug resistance which allows for a survival advantage in CML. …

… define therapeutic resistance, review mechanisms of resistance to kinase inhibitors, and
provide examples of therapeutic strategies to attempt to delay or overcome resistance. Given …

… kinases. We review clinically approved kinase inhibitors and the emergence of resistance
in … mechanisms. Currently emerging are pharmacological strategies able to circumvent …

… IC,, of kinase inhibitors against intact cells (… kinase inhibitors; (3) in vitro screens using
recombinant or purified receptors may not be completely predictive of the effect of tyrosine kinase …

… for imatinib-resistant patients. … mechanisms that lead to resistance to other kinase inhibitors
in solid tumors. This article is part of a Special Issue entitled: Inhibitors of Protein Kinases (…

… resistance mechanisms. AKT activation is a convergent feature of acquired EGFR … kinase
inhibitor resistance, across a spectrum of diverse, established upstream resistance mechanisms…

… been implicated in drug resistance. Additionally, overexpression of … resistant development.
In this review, we focus on the discussion of the molecular mechanisms of acquired resistance …

… resistance. These insights have created a rationale for the development of either multi-targeted
protein kinase inhibitors … potential mechanisms of resistance to targeted kinase inhibitors. …

… activates the PI3K/AKT pathway, leading to the development of resistance to EGFR-TKIs [58].
Crizotinib is a kinase inhibitor with multiple targets (including MET). Two case reports have …