… Here, we summarize the underlying mechanisms of TKIs resistance and discuss the potential
approaches to overcome it. We aim to provide a theoretical basis for future research and …

… This review discusses the mechanisms underlying resistance to the first-generation EGFR
TKIs and … strategies for overcoming resistance mechanisms. Factors contributing to resistance …

… resistance will be the major limitation preventing EGFR-targeted therapy from having greater
impact. Although several resistance mechanisms to EGFR tyrosine-kinase inhibitors (TKIs) …

… RET solvent front mutations are a recurrent mechanism of RET inhibitor resistance, … The
majority of resistance to selective RET inhibition may be driven by RET-independent resistance …

… (RTKIs), their current use in oncology, and mechanisms of resistance. We also describe
the technological advances of artificial intelligence, chemoproteomics, and microfluidics in …

… -resistant tumor clones limits the long-term benefit of these drugs in most patients. Resistance
to these kinase inhibitors … of the oncogenic kinase being the most common mechanism. We …

… of tyrosine kinase inhibitor (TKI) resistance mutations within and between different metastatic
GIST lesions and to examine the relationship between drug resistance and morphological …

… Resistance to BCR-ABL1 tyrosine kinase inhibitors may take the form of (left) point or
compound mutation-based, BCR-ABL1-dependent resistance or (middle) recruitment of alternative …

… potent and selective kinase inhibitors to further our understanding of resistance mechanisms;
(c… antitumor efficacy and disrupt resistance mechanisms; and (d) novel kinase targets in the …

… of action, and their inhibitory activity against specific kinase signaling … kinases by tyrosine
kinase inhibitors may contribute to the clinically observed anti-tumor activity, resistance, and …