… kinase (MAPK)/Ras signaling cascades. In clinical trials, highly selective or specific blocking
of only one of the kinases involved in these signaling pathways has … of signal transduction …

… used in conjunction with the other kinase inhibitors described in this chapter. As a control,
to demonstrate that the Ro 318220 or GF 109203X inhibitors are functioning, cells should be …

… Hyperactive JAK at the apex of these potent oncogenic signaling pathways therefore … kinase
inhibitors in different disease states. The JAK1/2 inhibitor ruxolitinib and the JAK3 inhibitor …

… the best tools to identify the molecular targets and signaling pathways involved in modulation
of p27Kip1 protein by HER2 signaling. Trastuzumab is found to upregulate the expression …

… finding led to the development of tyrosine kinase inhibitors (TKIs) that are highly … signaling
pathways closely interact but that PI3K signaling represents a partially independent pathway …

… signaling causes many diseases, and manipulating signaling pathways with kinase inhibitors
… Most kinase inhibitors target the conserved ATP-binding pocket; therefore specificity is a …

… expression or activity, such as PDGFR-β and IGF-IR, is thought to be conferred by parallel
activation of downstream signaling pathways that bypass the inhibited target. In addition, …

… tyrosine kinase. In view of the surge in development of small molecule kinase inhibitors for
… Preclinical assessment of the immunosuppressive effects of kinase inhibitors and human …

… of signaling pathways. This loss of redundancy renders the cancer cell highly dependent on
those signaling pathways … to agents that target these signaling pathways. The recognition of …

… of signaling pathways that use protein kinases often … kinases regulate most aspects of
normal cellular function. The pathophysiological dysfunction of protein kinase signaling pathways …