… drug's antinociceptive effect, but rather is more suggestive that nociceptive-induced signaling
(… In this regard, a peripheral-based mechanism of antinociception could indirectly diminish …

… Activation of glial cells and the extracellular signal-regulated kinase (ERK) signaling pathway
… the effects of tolerable doses of curcumin on the activation of astrocytes and ERK signaling …

… the hypothermic effects of morphine and fentanyl. Fourth, we determined whether JNK
signaling enhances antinociception and mediates tolerance to the anti-allodynic effects of chronic …

… antinociceptive effect of AR-A014418 administration against inflammatory pain may be due
to GSK-3β-mediated downstream inhibition of cytokine signaling … rapid antinociceptive effect …

… –cGMP–protein kinase G (PKG)–c-Jun N-terminal kinase (JNK) signaling pathway on the …
Relative to DPDPE and JWH-015, our findings supported the absence of antinociceptive …

… The purpose of the present study was therefore to evaluate the peripheral, spinal, and
supraspinal antinociceptive effects and some of the mechanisms underlying the action of the …

… Here, we show that the peripheral antinociceptive effect of … stimulation of PI3Kγ/AKT protein
kinase B (AKT) and culminated in … Because PI3Kγ may signal through AKT kinase (20), we …

… Furthermore, it has been reported that the Rho/Rho-kinase signal cascade is involved in the
central regulation of blood pressure because blockade of this pathway in the nucleus tractus …

… inhibitors of these kinases also reduced peripheral antinociception induced by U50488. …
peripheral antinociceptive effect of KOR is also dependent on activation of PI3Kγ/AKT signaling. …

… effect of the DIP. Initially, we observed that DIP-induced peripheral antinociceptive effect was
attenuated by a … AKT, a PI3Kγ downstream signaling kinase, is involved in the peripheral …