Spread of Extended-Spectrum β-Lactamase—Producing Klebsiella pneumoniae: Are β-Lactamase Inhibitors of Therapeutic Value?

L Piroth, H Aubé, JM Doise… - Clinical infectious …, 1998 - academic.oup.com
… The b-lactamase inhibitors used by either increase was not documented in this … b-lactamase
inhibitors may have a during nosocomial outbreak of multiresistant Klebsiella pneumoniae. …

Multidrug-resistant Klebsiella pneumoniae: mechanisms of resistance including updated data for novel β-lactam-β-lactamase inhibitor combinations

I Galani, I Karaiskos, H Giamarellou - Expert Review of Anti …, 2021 - Taylor & Francis
Klebsiella pneumoniae is currently one of the most pressing emerging issues in bacterial
resistance. Treatment of K.pneumoniae … new β-lactam/β-lactamase inhibitor combinations, …

[HTML][HTML] β-Lactamases and β-Lactamase Inhibitors in the 21st Century

CL Tooke, P Hinchliffe, EC Bragginton… - Journal of molecular …, 2019 - Elsevier
… coli and Klebsiella pneumoniae and non-fermenting species such as Pseudomonas
aeruginosa and Acinetobacter baumannii. Key enzyme families include TEM, SHV, CTX-M and …

First penicillin-binding protein occupancy patterns of β-lactams and β-lactamase inhibitors in Klebsiella pneumoniae

DS Sutaria, B Moya, KB Green, TH Kim… - Antimicrobial agents …, 2018 - Am Soc Microbiol
… Despite β-lactams serving as the cornerstone of our therapeutic armamentarium against
Klebsiella pneumoniae… diverse and clinically relevant β-lactams and β-lactamase inhibitors in K. …

… pneumoniae resistant to broad-spectrum cephalosporins and beta-lactam-beta-lactamase inhibitor combinations by hyperproduction of SHV-5 beta-lactamase

GL French, KP Shannon… - Journal of Clinical …, 1996 - Am Soc Microbiol
… An aminoglycoside- and ceftazidime-resistant strain of Klebsiella pneumoniae K2 producing
the extendedspectrum ß-lactamase SHV-5 infected or colonized 14 pediatric patients at Guy…

New β-lactamase inhibitors in the clinic

KM Papp-Wallace, RA Bonomo - Infectious Disease Clinics, 2016 - id.theclinics.com
… Imipenem-avibactam and cefepime-avibactam or aztreonam-avibactam and ceftaroline-avibactam
are effective against E coli and K pneumoniae carrying bla OXA-48 , respectively, but …

New β-lactamβ-lactamase inhibitor combinations

D Yahav, CG Giske, A Grāmatniece… - Clinical microbiology …, 2020 - Am Soc Microbiol
… Ceftazidime-avibactam is a potential drug for treating Enterobacterales producing
extended-spectrum β-lactamase (ESBL), Klebsiella pneumoniae carbapenemase (KPC), AmpC, and …

… inhibitor combinations and carbapenems in definitive treatment of bloodstream infections caused by cefotaxime-resistant Escherichia coli or Klebsiella pneumoniae

PNA Harris, M Yin, R Jureen, J Chew, J Ali… - … resistance and infection …, 2015 - Springer
… Extended-spectrum β-lactamase (ESBL) producing Enterobacteriaceae are often susceptible
in vitro to β-lactam/β-lactamase inhibitor (BLBLI) combination antibiotics, but their use has …

New β-lactamase inhibitors: a therapeutic renaissance in an MDR world

SM Drawz, KM Papp-Wallace… - Antimicrobial agents and …, 2014 - Am Soc Microbiol
β-lactamase enzymes to this serious clinical problem. This review highlights recent advances
in β-lactamase inhibitors … catalytically versatile β-lactamases (eg, Klebsiella pneumoniae

Roles of β-Lactamases and Porins in Activities of Carbapenems and Cephalosporins against Klebsiella pneumoniae

L Martínez-Martínez, A Pascual… - Antimicrobial agents …, 1999 - Am Soc Microbiol
… encoding various ESBLs and AmpC β-lactamase types, by studying the effect of an increased
inoculum, and by evaluating interactions with β-lactamase inhibitors. The contribution of …