A Klebsiella pneumoniae antibiotic resistance mechanism that subdues host defences and promotes virulence

TJ Kidd, G Mills, J Sá‐Pessoa, A Dumigan… - EMBO molecular …, 2017 - embopress.org
Klebsiella pneumoniae is an important cause of multidrug‐resistant infections worldwide.
Recent studies highlight the emergence of multidrug‐resistant K. pneumoniae strains which
show resistance to colistin, a last‐line antibiotic, arising from mutational inactivation of the
mgrB regulatory gene. However, the precise molecular resistance mechanisms of mgrB‐
associated colistin resistance and its impact on virulence remain unclear. Here, we
constructed an mgrB gene K. pneumoniae mutant and performed characterisation of its lipid …

Klebsiella pneumoniae antibiotic resistance identified by atomic force microscopy

V Ierardi, P Domenichini, S Reali, GM Chiappara… - Journal of …, 2017 - Springer
In the last decade the detection of the resistance of bacteria to antibiotics treatment,
developed by different kind of bacteria, is becoming a huge problem. We hereby present a
different approach to the current problem of detection of bacteria resistance to antibiotics.
Our aims were to use the atomic force microscopy (AFM) to investigate bacteria
morphological changes in response to antibiotics treatment and explore the possibility of
reducing the time required to obtain information on their resistance. In particular, we studied …
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