… In vitro, Klotho suppressed Na + -dependent uptake of phosphate and … , Klotho is an early
biomarker for CKD, and Klotho deficiency contributes to soft-tissue calcification in CKD. Klotho …

… of Klotho deficiency in CKD. a Putative mechanism of downregulation of Klotho expression
in CKD: in CKD/end-stage renal disease, multiple potential factors including loss of renal …

… kidney injury (AKI) and chronic kidney disease (CKD) are states of systemic Klotho deficiency,
making Klotho a very sensitive biomarker of impaired renal function. In addition to its role …

… disorders, and renal fibrosis in CKD. Based on the pathogenic mechanism of klotho deficiency
and klotho … 1, it is not difficult to understand that soluble klotho can serve as an early and …

… novel therapeutic agent for CKD patients. We will first discuss the recent literatures about
Klotho deficiency as a biomarker for CKD and its role in CKD-mineral and bone disorder (MBD) …

… kidney injury [ 30 ]. Thus, decrease in Klotho expression potentially accelerates renal
damage, leading to a deterioration spiral of Klotho expression and renal function. Because 1,25-…

… Alpha-Klotho (αKlotho) protein is encoded by the gene, Klotho, … starts to decline in chronic
kidney disease (CKD) stage 2 and … marker of decline in kidney function. Preclinical data from …

… how Klotho might impact age-related disease, this review focuses on what we actually
mean by the aging process, its relevance to chronic kidney disease (CKD) as a disease of …

… kidney protein, Klotho (α-Klotho), may link ageing, phosphate metabolism and inflammation.
Klotho deficiency … The best characterized function of Klotho is regulation of phosphate …

… of Klotho during kidney disease coupled with a negative impact of Klotho deficiency on kidney
disease … circle where kidney injury results in low kidney Klotho and Klotho downregulation …