… AQP4 null mice in models of cytotoxic brain edema. (A) Survival of wildtype vs. AQP4 knockout
mice … (B) (top) Brain sections of mice at 24 h after ischemic stroke produced by permanent …

… hypothesized that deletion of water channel aquaporin-4 (AQP4) is neuroprotective in global
cerebral ischemia. AQP4 is a water-selective transporting … 4, 5). We previously generated …

… water channel aquaporin-1 (AQP1) in microvascular endothelia and aquaporin-4 (AQP4) in
… active fluid transport in AQP1 and AQP4 knockout mice. Airspace–capillary osmotic water …

… or nontoxic inhibitors exist for any AQP. The purpose of this study was to generate and
characterize a transgenic null mouse lacking AQP4. AQP4 was initially cloned from rat lung (8). …

… To determine the contribution of AQP4 to water permeability in the initial inner medullary …
from wild-type and AQP4 knockout mice. The AQP4 knockout mice were previously found to …

… showed no abnormalities in AQP4-deficient mice, despite selective AQP4 expression in …
hypothesis that AQP4 is required for gastric acid secretion. The involvement of AQP4 in gastric …

… aquaporin-4 (AQP4) in maintaining blood–brain barrier integrity, structure and permeability
of the brain microvessels were investigated in adult AQP4 knockout mice… the AQP4 null mice. …

… AQP4 knockout mice indicated that AQP4 is the OAP protein (28). These observations
provide indirect evidence for a functional role of OAPs and AQP4 in skeletal muscle physiology. …

… Location of AQP4 Aquaporin 4 is polarized to endfeet of astrocytes adjacent to capillaries,
neurons, and neuronal synapses.7, 8 The highest density of astrocytic AQP4 exists in the …

… from studies using AQP4 −/− mice and of AQP4 expression following stroke. Here, we studied
… AQP4 knockout (AQP4 −/− ) mice are powerful tools to study the role of AQP4 after stroke. …