[HTML][HTML] Three distinct roles of aquaporin-4 in brain function revealed by knockout mice
… AQP4 null mice in models of cytotoxic brain edema. (A) Survival of wildtype vs. AQP4 knockout
mice … (B) (top) Brain sections of mice at 24 h after ischemic stroke produced by permanent …
mice … (B) (top) Brain sections of mice at 24 h after ischemic stroke produced by permanent …
[HTML][HTML] Greatly improved survival and neuroprotection in aquaporin-4-knockout mice following global cerebral ischemia
R Katada, G Akdemir, N Asavapanumas… - The FASEB …, 2014 - ncbi.nlm.nih.gov
… hypothesized that deletion of water channel aquaporin-4 (AQP4) is neuroprotective in global
cerebral ischemia. AQP4 is a water-selective transporting … 4, 5). We previously generated …
cerebral ischemia. AQP4 is a water-selective transporting … 4, 5). We previously generated …
Lung fluid transport in aquaporin-1 and aquaporin-4 knockout mice
C Bai, N Fukuda, Y Song, T Ma… - The Journal of …, 1999 - Am Soc Clin Investig
… water channel aquaporin-1 (AQP1) in microvascular endothelia and aquaporin-4 (AQP4) in
… active fluid transport in AQP1 and AQP4 knockout mice. Airspace–capillary osmotic water …
… active fluid transport in AQP1 and AQP4 knockout mice. Airspace–capillary osmotic water …
Generation and phenotype of a transgenic knockout mouse lacking the mercurial-insensitive water channel aquaporin-4.
T Ma, B Yang, A Gillespie, EJ Carlson… - The Journal of …, 1997 - Am Soc Clin Investig
… or nontoxic inhibitors exist for any AQP. The purpose of this study was to generate and
characterize a transgenic null mouse lacking AQP4. AQP4 was initially cloned from rat lung (8). …
characterize a transgenic null mouse lacking AQP4. AQP4 was initially cloned from rat lung (8). …
Fourfold reduction of water permeability in inner medullary collecting duct of aquaporin-4 knockout mice
CL Chou, T Ma, B Yang, MA Knepper… - American Journal of …, 1998 - journals.physiology.org
… To determine the contribution of AQP4 to water permeability in the initial inner medullary …
from wild-type and AQP4 knockout mice. The AQP4 knockout mice were previously found to …
from wild-type and AQP4 knockout mice. The AQP4 knockout mice were previously found to …
Gastric acid secretion in aquaporin-4 knockout mice
KS Wang, AR Komar, T Ma, F Filiz… - American Journal …, 2000 - journals.physiology.org
… showed no abnormalities in AQP4-deficient mice, despite selective AQP4 expression in …
hypothesis that AQP4 is required for gastric acid secretion. The involvement of AQP4 in gastric …
hypothesis that AQP4 is required for gastric acid secretion. The involvement of AQP4 in gastric …
Altered blood–brain barrier integrity in adult aquaporin-4 knockout mice
J Zhou, H Kong, X Hua, M Xiao, J Ding, G Hu - Neuroreport, 2008 - journals.lww.com
… aquaporin-4 (AQP4) in maintaining blood–brain barrier integrity, structure and permeability
of the brain microvessels were investigated in adult AQP4 knockout mice… the AQP4 null mice. …
of the brain microvessels were investigated in adult AQP4 knockout mice… the AQP4 null mice. …
Skeletal muscle function and water permeability in aquaporin-4 deficient mice
B Yang, JM Verbavatz, Y Song… - … of Physiology-Cell …, 2000 - journals.physiology.org
… AQP4 knockout mice indicated that AQP4 is the OAP protein (28). These observations
provide indirect evidence for a functional role of OAPs and AQP4 in skeletal muscle physiology. …
provide indirect evidence for a functional role of OAPs and AQP4 in skeletal muscle physiology. …
The role of aquaporin 4 in the brain
C Iacovetta, E Rudloff, R Kirby - Veterinary Clinical Pathology, 2012 - Wiley Online Library
… Location of AQP4 Aquaporin 4 is polarized to endfeet of astrocytes adjacent to capillaries,
neurons, and neuronal synapses.7, 8 The highest density of astrocytic AQP4 exists in the …
neurons, and neuronal synapses.7, 8 The highest density of astrocytic AQP4 exists in the …
Improved long-term outcome after transient cerebral ischemia in aquaporin-4 knockout mice
… from studies using AQP4 −/− mice and of AQP4 expression following stroke. Here, we studied
… AQP4 knockout (AQP4 −/− ) mice are powerful tools to study the role of AQP4 after stroke. …
… AQP4 knockout (AQP4 −/− ) mice are powerful tools to study the role of AQP4 after stroke. …
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