… Here, we describe generation of LOX-1 knockout (KO) mice … (P<0.01 versus wild-type mice).
To address whether endothelial … LOX-1 KO mice with LDLR KO mice and fed these mice 4% …

… on the first LOX-1 knockout mice model showing reduced … LOX-1–knockout mice are
homozygous-viable, possessing a … LOX-1–knockout mice with LDL receptor (LDLR)–knockout …

… if LOX-1 deletion in the LDLR KO mice will attenuate collagen deposition. Indeed, our
study shows that collagen deposition is markedly reduced in the LDLR KO mice with LOX-1 …

… the role of LOX-1 in endothelial dysfunction in ApoE KO mice. Impaired vasodilation to
ACh in ApoE KO mice is partially restored by NAD(P)H oxidase inhibitor. Anti–LOX-1 restored …

… LOX-1 to the atherogenic process has been confirmed in animal models; LOX-1 knockout
mice … ; on the contrary, LOX-1 overexpressing mice present an accelerated atherosclerotic …

… of the AT1 receptor in LOX1 KO mice was lower than wild-type mice both before and after …
were attenuated in LOX1 KO mice compared with wild-type mice.LOX-1 KO mice infused with …

… ApoE knockout mice on a C57BL/6 background. Offsprings carrying the LOX-1 transgene
and being heterozygous for the ApoE locus were used to generate LOX-1TG/ApoE −/− mice (…

… Moreover, adipose tissues collected from LOX-1 KO mice were … -1 by sandwich ELISA using
mouse monoclonal anti-human LOX-1 antibody and chicken monoclonal anti-human LOX-1 …

… Importantly, LOX-1 KO and LDLr–LOX-1 double KO mice showed diminished CD68 … Wild
type, LDLr KO, LOX-1 KO and LDLr-LOX-1 double KO mice were anesthetized and their aortas …

… First, although we studied PCSK9 signalling in LOX-1 gene KO mice, further experiments
in LOX-1 transgenic aorta should be considered in the future. Secondly, we focused our …