[HTML][HTML] Antimicrobial resistance in the global health network: known unknowns and challenges for efficient responses in the 21st century

TM Coque, R Cantón, AE Pérez-Cobas… - Microorganisms, 2023 - mdpi.com
Antimicrobial resistance (AMR) is one of the Global Health … not exhaustive revision of the
known unknowns about how to … they represent for surveillance, antimicrobial stewardship, and …

Addressing the unknowns of antimicrobial resistance: quantifying and mapping the drivers of burden

GM Knight, C Costelloe, KA Murray… - Clinical Infectious …, 2018 - academic.oup.com
… For example, high antimicrobial use occurs in the agricultural environment, but we do not
know … of agricultural antimicrobial use to clinical AMR risk thus remains unknown. This lack of a …

[HTML][HTML] Antimicrobial stewardship in the ICU in COVID-19 times: the known unknowns

J Schouten, J De Waele, C Lanckohr, D Koulenti… - … Journal of Antimicrobial …, 2021 - Elsevier
… Since the start of the COVID-19 pandemic, there has been concern about the concomitant
rise of antimicrobial resistance. While bacterial co-infections seem rare in COVID-19 patients …

Antimicrobial resistance surveillance in the genomic age

AG McArthur, KK Tsang - Annals of the New York Academy of …, 2017 - Wiley Online Library
unknowns”29, 30 is readily applicable to AMR surveillance.1 The known knowns are the
published … The known unknowns are the genes or sequence variants that may be present in the …

Cryptic or silent? The known unknowns, unknown knowns, and unknown unknowns of secondary metabolism

PA Hoskisson, RF Seipke - MBio, 2020 - Am Soc Microbiol
… The majority of the confusion has crept into literature when discussing the Known Unknowns
and the Unknown Knowns. This is where it is important for the term “cryptic” to be used …

The challenge of antimicrobial resistance: what economics can contribute

LSJ Roope, RD Smith, KB Pouwels, J Buchanan… - Science, 2019 - science.org
… are now under threat from antimicrobial resistance (AMR). Here, we exclusively consider
resistance against antibiotics used to treat bacterial infections. Resistance is largely driven by …

Elucidating the known unknowns of sepsis

JT Jacob - Critical Care Medicine, 2015 - journals.lww.com
… In patients with severe sepsis with unknown or unreported organisms, the present study
found a higher overall mortality than in patients with identified pathogens (36% vs 27%). There …

Known knowns, known unknowns and unknown unknowns in prokaryotic transposition

P Siguier, E Gourbeyre, M Chandler - Current opinion in microbiology, 2017 - Elsevier
… Although the phenomenon of transposition has been known for over 60 years, its overarching
importance in modifying and streamlining genomes took some time to recognize. In spite …

[HTML][HTML] Antimicrobial resistance: one world, one fight!

…, World Healthcare-Associated Infections Resistance … - 2015 - Springer
… antibiotics select for resistance in numerous species of bacteria which then renders antimicrobial
treatment ineffective. Almost all countries face increased antimicrobial resistance (AMR)…

Antimicrobial resistance: implications and costs

P Dadgostar - Infection and drug resistance, 2019 - Taylor & Francis
… major reasons behind the emergence of antimicrobial resistance. In addition, the … resistant
genes through horizontal gene transfer are significant contributors to antimicrobial resistance. …