… special histology and co-occurring mutations in KRAS-mutant lung cancer. Initial studies [13…
, KRAS mutations might be present not only in LADC but also in squamous cell lung cancer. …

… in KRAS-mutant lung cancer xenografts, a KRAS-mutant patient-derived xenograft, and a
genetically engineered mouse model (GEMM) of Kras G12D -induced lung adenocarcinoma …

… (KRAS), and mutations in EGFR and KRAS appear to be mutually exclusive. Even though
KRAS mutations … of determining KRAS tumor status. Recent studies indicate that patients with …

For decades, KRAS mutant lung adenocarcinomas (LUAD) have been refractory to … KRAS
and downstream targets with acceptable toxicities. The recent development of selective KRAS …

… -driven lung cancers that commonly arise in never or light smokers, KRAS mutations are
typically … ), and only ≈5–10% of KRAS-mutant lung cancers arise in never or light smokers [1,2]. …

… EGFR mutations in lung cancer (4–9). Below, we focus on the role of KRAS mutations in this
… Recently, we evaluated the frequency of KRAS mutations in lung adenocarcinomas from …

… significance of KRAS mutations in lung adenocarcinomas, we analyzed the findings of
patients with KRAS-mutant lung adenocarcinomas from the Lung Cancer Mutation Consortium (…

… , effective KRAS-targeted therapies still remain elusive. KRAS mutant lung cancers have
worse … the critical need for novel agents targeting KRAS-driven NSCLC. Numerous therapeutic …

… sensitivity of KRAS mutant lung cancer to heat-shock protein-90 (HSP-90) inhibitors, and
mouse tumor models revealed dramatic regression of KRAS-mutant lung cancer with HSP-90 …

… In terms of characterization of PD-L1 expression in KRAS mutation subtypes, we found that
any KRAS mutation subtype had a greater likelihood of PD-L1 expression, across all major …