Molecular Pathways: The Basis for Rational Combination Using MEK Inhibitors in KRAS-Mutant Cancers
S Okumura, PA Jänne - Clinical cancer research, 2014 - AACR
… -mutant cancers. In vitro studies demonstrated a tendency toward sensitivity to MEK inhibitors
in cell lines harboring KRAS mutations compared with those without KRAS mutations (18, …
in cell lines harboring KRAS mutations compared with those without KRAS mutations (18, …
PI3K pathway activation mediates resistance to MEK inhibitors in KRAS mutant cancers
S Wee, Z Jagani, KX Xiang, A Loo, M Dorsch, YM Yao… - Cancer research, 2009 - AACR
… of KRAS mutant cancer cells to MEK inhibitor varied extensively despite efficient MEK pathway
inhibition in … We noted that the majority of MEK inhibitor–insensitive cell lines harbored …
inhibition in … We noted that the majority of MEK inhibitor–insensitive cell lines harbored …
RAF suppression synergizes with MEK inhibition in KRAS mutant cancer cells
… To gather insights into genes capable of complementing MEK inhibition in KRAS mutant cells
insensitive … We propose that, in a KRAS mutant background, MEK inhibition triggers KRAS …
insensitive … We propose that, in a KRAS mutant background, MEK inhibition triggers KRAS …
Mechanism of MEK inhibition determines efficacy in mutant KRAS-versus BRAF-driven cancers
G Hatzivassiliou, JR Haling, H Chen, K Song, S Price… - Nature, 2013 - nature.com
… known as cobimetinib), a MEK inhibitor currently in phase III clinical trials. … MEK in KRAS-mutant
tumours versus BRAF-mutant tumours can be exploited through the design of inhibitors …
tumours versus BRAF-mutant tumours can be exploited through the design of inhibitors …
Disruption of CRAF-mediated MEK activation is required for effective MEK inhibition in KRAS mutant tumors
P Lito, A Saborowski, J Yue, M Solomon, E Joseph… - Cancer cell, 2014 - cell.com
… MEK inhibitors in KRAS mutant tumors vary, owing to specific properties of drug-bound MEK…
We hypothesized that the ability of MEK inhibitors to inhibit the proliferation of KRAS mutant …
We hypothesized that the ability of MEK inhibitors to inhibit the proliferation of KRAS mutant …
Back to the bench? MEK and ERK inhibitors for the treatment of KRAS mutant lung adenocarcinoma
J Kohler, M Catalano… - Current Medicinal …, 2018 - ingentaconnect.com
… state of MEK and ERK inhibitors in pre-clinical models and in human clinical trials for … MEK
inhibitor to date [75], single agent MEK inhibitors have only marginal activity in KRAS mutant …
inhibitor to date [75], single agent MEK inhibitors have only marginal activity in KRAS mutant …
A MEK Inhibitor Abrogates Myeloproliferative Disease in Kras Mutant Mice
N Lyubynska, MF Gorman, JO Lauchle… - Science translational …, 2011 - science.org
… To investigate the mechanism of this response to MEK inhibition, we first explored
whether PD0325901 treatment eliminated Kras mutant cells from the bone marrow. We used …
whether PD0325901 treatment eliminated Kras mutant cells from the bone marrow. We used …
KRAS dimerization impacts MEK inhibitor sensitivity and oncogenic activity of mutant KRAS
… wild-type KRAS-dependent fitness of human and murine KRAS mutant LUAD … MEK inhibition.
These effects are abrogated when wild-type KRAS is replaced by KRAS D154Q , a mutant …
These effects are abrogated when wild-type KRAS is replaced by KRAS D154Q , a mutant …
MEK inhibitors for the treatment of NRAS mutant melanoma
S Sarkisian, D Davar - Drug Design, Development and Therapy, 2018 - Taylor & Francis
… /MEK inhibitors in the treatment of this disease. We describe the recent development of
the selective MEK inhibitor … with AKT inhibitor MK-2206 in KRAS mutant cancers, Citation101 …
the selective MEK inhibitor … with AKT inhibitor MK-2206 in KRAS mutant cancers, Citation101 …
MEK inhibition in non-small cell lung cancer
TE Stinchcombe, GL Johnson - Lung cancer, 2014 - Elsevier
… mutations of genes in addition to KRAS mutations impact the activity of MEK inhibitors, or
specific subsets of KRAS mutations may be resistant or susceptible to MEK inhibition. Other …
specific subsets of KRAS mutations may be resistant or susceptible to MEK inhibition. Other …
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